• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Psychiatry Research. Neuroimaging >Intra-individual variability in neurocognitive function in schizophrenia: relationships with the corpus callosum
【24h】

Intra-individual variability in neurocognitive function in schizophrenia: relationships with the corpus callosum

机译：精神分裂症中神经认知功能的个体内变异：与语料库胼callosum的关系

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Patients with schizophrenia not only have impairments in neurological function, but also have instability and variability in neurocognitive function. However, previous researchers have not fully studied the relationships between dispersion across multiple neurocognitive domains and white matter (WM) structures of the brain. This study focuses on intra-individual variability (IIV) in patients with schizophrenia and its relationship with WM integrity of the corpus callosum (CC). Thirty-eight patients with schizophrenia were enrolled in the study. All subjects underwent assessments of neurocognitive function using the Korean-Wechsler Adult Intelligence Scale-Revised (K-WAIS-R) and the severity of clinical symptoms using the Positive and Negative Syndrome Scale (PANSS). IIV across subtests of the K-WAIS-R was calculated using the Holtzer's equation. Tract-based spatial statistics were used to analyze diffusion tensor images. In subjects with schizophrenia, a negative correlation was found between IIV in performance intelligence quotient (PIQ) and fractional anisotropy (FA) values in the genu of the CC. In addition, FA values of the same region were negatively correlated with the total and subscale scores of positive symptoms and general psychopathology from the PANSS. Our findings suggest that the genu of the CC may play an important role in IIV in PIQ and syrnptomatology in patients with schizophrenia.
机译：精神分裂症患者不仅具有神经功能的损伤，而且具有神经认知功能的不稳定性和变异性。然而，以前的研究人员尚未完全研究大脑的多种神经认知结构域和白质（WM）结构之间的色散之间的关系。本研究侧重于精神分裂症患者的个体内变异性（IIV）及其与Corpus愈伤组织（CC）的WM完整性的关系。在研究中注册了三十八名精神分裂症患者。所有受试者都使用韩国福建人成年智力规模修订（K-WAIS-R）对神经认知功能进行评估，以及使用正面和负综合征规模（平底锅）的临床症状的严重程度。使用Holtzer的方程计算K-WAIS-R的SubTests。基于道的空间统计分析扩散张量图像。在具有精神分裂症的受试者中，在综合性智能商（PIQ）和CC中的绩效智能商（PIQ）和分数各向异性（FA）值之间发现了负相关。此外，同一区域的成分与来自平底锅的阳性症状和一般性精神病理学的总和和次额等分数负相关。我们的研究结果表明，CC的Gy of在精神分裂症患者的PIQ和Syrnptomatology中发挥着重要作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号