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Impact of substance use disorder on gray matter volume in schizophrenia

机译:物质使用障碍对精神分裂症灰质体积的影响

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Substance use may confound the study of brain structure in schizophrenia. We used voxel-based morphometry (VBM) to examine whether differences in regional gray matter volumes exist between schizophrenia patients with (n =?92) and without (n?=?66) clinically significant cannabis and/or alcohol use histories compared to 88 healthy control subjects. Relative to controls, patients with schizophrenia had reduced gray matter volume in the bilateral precentral gyrus, right medial frontal cortex, right visual cortex, right occipital pole, right thalamus, bilateral amygdala, and bilateral cerebellum regardless of substance use history. Within these regions, we found no volume differences between patients with schizophrenia and a history of cannabis and/or alcohol compared to patients with schizophrenia without a clinically significant substance use history. Our data support the idea that a clinically meaningful history of alcohol or cannabis use does not significantly compound the gray matter deficits associated with schizophrenia.
机译:物质用途可能会混淆精神分裂症中脑结构的研究。我们使用基于体的形态学(VBM)来检查精神分裂症患者(n =α92)和没有(n?=Δ66)的临床显着大麻和/或酒精使用历史的临床上存在差异灰质体积的差异。与88相比,临床显着的大麻和/或酒精使用历史健康的对策。相对于对照组,精神分裂症患者在双侧前术过度的灰质体积减少,右侧内侧颅骨酱,右眼皮层,右侧枕骨,右枕头,双侧杏仁杆菌和双侧小脑,无论物质使用历史如何。在这些区域内,我们发现精神分裂症患者与大麻和/或酒精历史之间的体积差异与具有精神分裂症的患者没有临床显着的物质使用历史。我们的数据支持临床上有意义的酒精或大麻使用的历史并没有显着复制与精神分裂症相关的灰质缺陷。

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