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首页> 外文期刊>Psychiatry Research. Neuroimaging >Amygdala reactivity and connectivity during social and non-social aversive stimulation in social anxiety disorder
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Amygdala reactivity and connectivity during social and non-social aversive stimulation in social anxiety disorder

机译：Amygdala在社交焦虑症的社会和非社会厌恶刺激期间的反应性和连通性

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Social anxiety disorder (SAD) is characterized by exaggerated amygdala reactivity in response to symptom provocation, but it is unclear if such hyper-reactivity is elicited by disorder-specific challenges only or characterizes reactions to aversive stimuli in general. Here, using functional magnetic resonance imaging in 14 patients with SAD, as compared to 12 healthy controls, we found that amygdala hyper-reactivity is confined to disorder-relevant social stimulation. SAD patients displayed increased amygdala reactivity to fearful as compared to neutral facial pictures, but not in response to generally aversive but mainly non-social stimulation when compared to neutral pictorial stimuli taken from the International Affective Picture System. The increased amygdala reactivity was not mediated by an altered prefrontal inhibition among SAD patients as compared to controls, suggesting increased bottom-up processes rather than attenuated top-down control. In conclusion, the enhanced amygdala reactivity in SAD seems specific to socially relevant stimuli rather than aversive stimuli in general.
机译：社交焦虑症（悲伤）的特征在于夸张的杏仁菌反应性响应症状挑衅，但如果通过紊乱特异性挑战引发这种超反应性，则目前尚不清楚，或者将厌恶刺激的反应引发或表征厌恶刺激。在这里，在14例悲伤患者中使用功能磁共振成像，与12种健康对照相比，我们发现杏仁达高反应性被局限于紊乱相关的社会刺激。悲伤的患者与中性面部图片相比，令人恐惧的艾比达拉巴的反应性增加，但与一般厌恶而言，而不是从国际情感图像系统中获取的中性图形刺激相比，这主要是非社会刺激。与对照组相比，患者在悲伤患者中的改变前逆转抑制增加，施用增加，表明增加了自下而上的过程，而不是减弱自上而下控制。总之，令人悲伤的杏仁达拉的反应性似乎是特定于社会相关的刺激而不是厌恶刺激。

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