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首页> 外文期刊>Psychiatry Research. Neuroimaging >Behavioral and neural correlates of memory suppression in subthreshold depression
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Behavioral and neural correlates of memory suppression in subthreshold depression

机译：亚阈值凹陷中记忆抑制的行为和神经相关性

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Many studies have demonstrated that healthy individuals can intentionally control memory. However, little is known about the behavioral and neural mechanisms of memory control in those with subthreshold depression (SD), a highly prevalent condition associated with severe impairments and a significant social burden. In this study, we used functional magnetic resonance imaging (fMRI) and a generalized form of task-dependent psychophysiological interaction (gPPI) analysis during the think/no-think task to examine the brain mechanism of memory suppression in SD participants. The behavioral results revealed that SD participants were unable to suppress negative memories. Neuroimaging data revealed that the SD group showed greater activation than the healthy control (HC) group in the prefrontal gyrus during memory processing. Moreover, gPPI analysis showed that the SD group had significantly lower right hippocampal functional coupling with the dorsolateral prefrontal cortex during negative memory suppression than the HC group. These results indicated that SD participants recruited more frontal control resources for memory suppression because of executive and prefrontal inhibitory dysfunction. However, the abnormal prefrontal-hippocampal inhibitory pathway resulted in a failure of the memory control process when the stimuli were negative. These findings provide some evidence for understanding why SD individuals have inefficient memory control of negative memories.
机译：许多研究表明，健康的个体可以故意控制内存。然而，对于具有亚阈值凹陷（SD）的内存控制的行为和神经机制，具有很少的普遍性的条件，与严重损​​伤相关，并且具有重要的社会负担，毫无熟悉。在这项研究中，我们使用功能磁共振成像（FMRI）和思维依赖性的心理生理学相互作用（GPPI）分析的普遍形式，以检查SD参与者中记忆抑制的大脑机制。行为结果表明，SD参与者无法抑制负回忆。神经成像数据显示，SD组在存储器处理期间，SD组显示比前额相回归中的健康对照（HC）组更大的活化。此外，GPPI分析表明，SD组在阴性记忆抑制期间与高温抑制期间的右侧海马功能耦合明显较低。这些结果表明，由于执行和前额叶抑制功能障碍，SD参与者招募了更多的正面控制资源进行记忆抑制。然而，当刺激为阴性时，异常前额相海马抑制途径导致存储器控制过程失败。这些调查结果提供了一些证据，了解为什么SD个人具有效率低下记忆的记忆控制。

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