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首页> 外文期刊>Psychiatry Research. Neuroimaging >The long-term effects of single and repeated subanaesthetic ketamine administration on regional cerebral blood flow in healthy dogs measured with Tc-99m-HMPAO SPECT
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The long-term effects of single and repeated subanaesthetic ketamine administration on regional cerebral blood flow in healthy dogs measured with Tc-99m-HMPAO SPECT

机译：用TC-99M-HMPAO SPECT测量的单一和重复亚体育酮酮酮酮酮酮酮酮酮酮对健康犬的区域脑血流量的影响

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Subanaesthetic ketamine has recently been established as an effective and rapid treatment for major depressive disorder showing antidepressant effects for up to 1 week on average. The use of repeated ketamine infusions has been put forward to augment and to prolong the antidepressant response and increase the remission rates. The underlying neurobiological mechanisms responsible for ketamine's antidepressant effects remain unclear. Nevertheless, it has been shown, both in dogs and humans, that ketamine can alter neuronal perfusion and therefore neuronal function in brain regions involved in psychiatric and behavioural disorders. Consequently, the aim of the current placebo controlled study was to assess the long-term effects on cerebral perfusion of single and repeated subanaesthetic ketamine infusions in dogs. Twelve healthy, laboratory dogs were scanned at six different time points following single and repeated ketamine administration, using Single Photon Emission Computed Tomography with the radiotracer Tc-99m-hexamethylpropylene amine oxime. We hypothesised that repeated infusions could lead to more prolonged perfusion alterations in brain regions critical for behaviour regulation. We found that repeated subanaesthetic ketamine administration did not result in more prolonged cerebral perfusion alterations compared to a single ketamine administration.
机译：最近已经建立了Subanaeesthethethethetic氯胺酮，其为主要抑郁症的有效和快速的治疗，显示平均抗抑郁症最多1周的抗抑郁作用。已经提出了反复的氯胺酮输注来增加并延长抗抑郁药反应并增加缓解率。负责氯胺酮抗抑郁作用的潜在的神经生物学机制仍然尚不清楚。尽管如此，爪子和人类都显示出来，即氯胺酮可以改变神经元灌注，从而改变脑区中的神经元功能，涉及精神病和行为障碍。因此，目前安慰剂对照研究的目的是评估狗中单双和重复亚麻酮酮输注的长期效应。在单一和重复的氯胺酮给药后，使用单一光子发射计算机断层扫描，在六种不同的时间点扫描12个健康，在六种不同的时间点扫描了雷氨酸Tc-99m-六甲基丙烯肟。我们假设反复输注可能导致脑区对行为调节至关重要的脑区更长的灌注改变。我们发现，与单一氯胺酮给药相比，重复的Subanaeesthethic氯胺酮施用不会导致更长的脑灌注改变。

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