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首页> 外文期刊>Psychiatry Research. Neuroimaging >Hippocampal volume and depression among young children
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Hippocampal volume and depression among young children

机译：幼儿中的海马体积和抑郁症

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Clinical depression can occur in young children as early as age three. This very early onset variant of depression shows the same clinical features with developmental adjustments as depression that onsets later in life. One robust neural feature of adult depression is reduced hippocampal volume. We measured hippocampal volume in a sample of 35 children aged 4-7 who were either in a clinical trial for preschool onset depression or were recruited from the community. We used T1 MPRAGE acquisitions on a Siemen's Scanner, with Freesurfer 5.3 used to segment the hippocampus. Depression was measured using the K-SADS early childhood (K-SADS-EC) to create a dimensional depression severity score and the Child Behavior Checklist (CBCL) Depression T-Score. Multilevel models indicated that greater depression severity as measured by either the CBCL Depression Score or the K-SADS-EC was associated with lower hippocampal volume, even controlling for total gray matter, maternal depression, income-to-needs ratio, and stressful life events. These data indicate evidence for reduced hippocampal volume among children with PO-MDD who were more severely depressed. Findings are consistent with the idea that hippocampal volume reductions are an early occurring associated neural marker of MDD, particularly for more severe depression.
机译：临床抑郁症可能发生在幼儿早期三岁。这种早期的抑郁症变异显示出与发育调整相同的临床特征，作为抑郁症的抑郁症，在后面的生活中持续。成人抑郁症的一个鲁棒神经特征降低了海马体积。我们在4-7岁的35岁儿童样品中测量了海马体积，谁在临床试验中进行学龄前发病抑郁症或被招募社区招募。我们在西门子的扫描仪上使用了T1 Mprage采集，用于段用于分割海马的FreeSurfer 5.3。使用K-Sads早期儿童（K-SADS-EC）测量抑郁症，以创造尺寸抑郁严重程度和儿童行为核对表（CBCL）抑郁T-得分。多级模型表明，通过Cbcl抑制得分或K-SADS-EC测量的更大的抑郁严重程度与较低的海马体积相关，甚至控制总灰质，母体抑郁，需求比和压力生活事件。这些数据表明PO-MDD中儿童的海马体积减少的证据是更严重抑郁的。结果符合海马体积减少是MDD的早期相关神经标志物的想法，特别是对于更严重的抑郁症。

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