• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Psychiatry Research. Neuroimaging >Longitudinal changes in striatum and sub-threshold positive symptoms in individuals with an 'at risk mental state' (ARMS)
【24h】

Longitudinal changes in striatum and sub-threshold positive symptoms in individuals with an 'at risk mental state' (ARMS)

机译：纹状体和亚阈值阳性症状的纵向变化，个人中的“危险精神状态”（武器）

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Recent studies have revealed that several psychotic symptom changes observed in the 'at risk mental state' (ARMS) are associated with changes in the striatum. We investigated if structural changes in the striatum are associated with recovery of sub-threshold psychotic symptoms in subjects with an ARMS who did not develop psychosis (ARMS-N). Sixteen healthy controls and 42 subjects with an ARMS participated in this study. Striatal volumes (caudate, putamen, and nucleus accumbens) were analyzed using MRI. The sub-threshold psychotic symptoms of the subjects with an ARMS were measured using the SOPS. Imaging and symptoms were reevaluated after 52 weeks. Significant right putamen volume reduction was observed at the follow-up in ARMS-N subjects. Improvement in sub-threshold positive symptoms significantly correlated with an increase in volume in the right accumbens at follow up. No relationship was found for negative symptoms. From these findings, the association between improvement in sub-threshold positive symptoms and an increase in the volume of the right accumbens may suggest that changes in the accumbens, which is a major site for dopamine innervation, are associated with symptom recovery. These findings may point to neurobiological resilience that may be associated with lower transition to psychosis.
机译：最近的研究表明，在“危险精神状态”（武器）中观察到的若干精神病症状变化与纹章的变化有关。我们调查了纹状体的结构变化与伴侣的副门阈值精神病症状的恢复有关，武器没有发展精神病（Arms-N）。 16个健康的控制和42名受试者参加了这项研究。使用MRI分析纹纹体积（尾部，腐烂和核常压）。使用SOP测量具有臂的受试者的子阈值精神病症状。在52周后重新评估成像和症状。在Arms-N受试者的后续观察到显着的正确腐凝体积减少。亚阈值阳性症状的改善与后续右侧的右侧屈服的增加的增加显着相关。对消极症状没有任何关系。从这些发现，亚阈值阳性症状的改善之间的关联和右距离的体积增加可能表明，该宫颈的变化是多巴胺支配的主要部位，与症状恢复有关。这些发现可能指向神经能源的弹性，可能与对精神病的过渡较低。

著录项

  • 来源
    《Psychiatry Research. Neuroimaging》 |2019年第2019期|共6页
  • 作者

    Katagiri Naoyuki; Pantelis Christos; Nemoto Takahiro; Tsujino Naohisa; Saito Junichi; Hori Masaaki; Yamaguchi Taiju; Funatogawa Tomoyuki; Mizuno Masafumi;

  • 作者单位

    Toho Univ Sch Med Dept Neuropsychiat Ota Ku 6-11-1 Omorinishi Tokyo 1438541 Japan;

    Univ Melbourne Melbourne Neuropsychiat Ctr Dept Psychiat Carlton Vic Australia;

    Toho Univ Sch Med Dept Neuropsychiat Ota Ku 6-11-1 Omorinishi Tokyo 1438541 Japan;

    Toho Univ Sch Med Dept Neuropsychiat Ota Ku 6-11-1 Omorinishi Tokyo 1438541 Japan;

    Toho Univ Sch Med Dept Neuropsychiat Ota Ku 6-11-1 Omorinishi Tokyo 1438541 Japan;

    Juntendo Univ Dept Radiol Sch Med Bunkyo Ku Tokyo Japan;

    Toho Univ Sch Med Dept Neuropsychiat Ota Ku 6-11-1 Omorinishi Tokyo 1438541 Japan;

    Toho Univ Sch Med Dept Neuropsychiat Ota Ku 6-11-1 Omorinishi Tokyo 1438541 Japan;

    Toho Univ Sch Med Dept Neuropsychiat Ota Ku 6-11-1 Omorinishi Tokyo 1438541 Japan;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经病学与精神病学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号