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Hippocampal functional connectivity-based discrimination between bipolar and major depressive disorders

机译：双相和主要抑郁症之间基于海马功能的连通性歧视

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摘要

Despite the impressive advancements in the neuropathology of mood disorders, patients with bipolar disorder (BD) are often misdiagnosed on the initial presentation with major depressive disorder (MDD). With supporting evidence from neuroimaging studies, the abnormal functional connectivity (FC) of the hippocampus has been associated with various mood disorders, including BD and MDD. However, the features of the hippocampal FC underlying MDD and BD have not been directly compared. This study aims to investigate the hippocampal resting-state FC (rsFC) analyses to distinguish these two clinical conditions. Resting-state functional magnetic resonance imaging (fMRI) data was collected from a sample group of 30 patients with BD, 29 patients with MDD and 30 healthy controls (HCs).
机译：尽管情绪障碍的神经病理学令人印象深刻，但双相障碍（BD）的患者常常在具有重大抑郁症（MDD）的最初介绍中误诊。 通过来自神经影像研究的支持证据，海马的异常功能连接（FC）已经与各种情绪障碍有关，包括BD和MDD。 然而，尚未直接比较海马FC和BD的海马FC的特征。 本研究旨在探讨海马休息状态FC（RSFC）分析以区分这两个临床病症。 从30例BD，29例MDD患者和30名健康对照（HCS）的样本组中收集休息状态功能磁共振成像（FMRI）数据。

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  • 来源
    《Psychiatry Research. Neuroimaging》 |2019年第2019期|共8页
  • 作者

    Fateh Ahmed Ameen; Long Zhiliang; Duan Xujun; Cui Qian; Pang Yajing; Farooq Muhammad Umar; Nan Xiaoyu; Chen Yuyan; Sheng Wei; Tang Qin; Chen Huafu;

  • 作者单位

    Univ Elect Sci &

    Technol China Clin Hosp MOE Key Lab Neuro Informat Chengdu Brain Sci Inst;

    Southwest Univ Fac Psychol Sleep &

    Neuroimaging Ctr Chongqing Peoples R China;

    Univ Elect Sci &

    Technol China Clin Hosp MOE Key Lab Neuro Informat Chengdu Brain Sci Inst;

    Univ Elect Sci &

    Technol China Sch Polit Sci &

    Publ Adm Chengdu Sichuan Peoples R China;

    Univ Elect Sci &

    Technol China Clin Hosp MOE Key Lab Neuro Informat Chengdu Brain Sci Inst;

    Univ Elect Sci &

    Technol China Inst Fundamental &

    Frontier Sci Chengdu Sichuan Peoples R China;

    Univ Elect Sci &

    Technol China Clin Hosp MOE Key Lab Neuro Informat Chengdu Brain Sci Inst;

    Univ Elect Sci &

    Technol China Clin Hosp MOE Key Lab Neuro Informat Chengdu Brain Sci Inst;

    Univ Elect Sci &

    Technol China Clin Hosp MOE Key Lab Neuro Informat Chengdu Brain Sci Inst;

    Univ Elect Sci &

    Technol China Clin Hosp MOE Key Lab Neuro Informat Chengdu Brain Sci Inst;

    Univ Elect Sci &

    Technol China Clin Hosp MOE Key Lab Neuro Informat Chengdu Brain Sci Inst;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经病学与精神病学;
  • 关键词

    Major depressive disorder; Bipolar disorder; Hippocampus; Functional connectivity;

    机译：主要抑郁症;双相障碍;海马;功能性连接;

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