首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Major Depressive Disorder in Medical Illness: A Review of Assessment, Prevalence, and Treatment Options
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Major Depressive Disorder in Medical Illness: A Review of Assessment, Prevalence, and Treatment Options

机译:医疗疾病的主要抑郁症:评估,患病率和治疗方案综述

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摘要

Major depression, as well as other depressive disorders, is commonly comorbid with other medical illnesses, particularly chronic and systemic medical illnesses. The co-occurrence of the disorders is so common that it challenges our notions of the meaning of comorbidity and our desire to neatly separate psychiatric and medical illnesses. The overlap between symptoms of physical illness and the neurovegetative symptoms of major depression and the initial normative emotional response to physical illness add to the challenge of accurate diagnosis and timely treatment of depression in the medically ill. We review the literature on the comorbidity of depression and the various medical illnesses, including diagnostic and treatment approaches. The differential diagnosis for major depression among medically ill patients should include delirium and medication-induced symptoms. We suggest that major depression itself may be best conceptualized as a systemic illness whose pathophysiology overlaps with other systemic medical illnesses. The initial treatment strategies for major depression in medical illness are like those for the general population; however, the comorbid medical illnesses may interfere with remission. To illustrate these points, we describe a patient with clinical characteristics covered in this review who experienced major depression as well as several chronic illnesses, including hypersensitivity pneumonitis, multiple sclerosis, chronic pain due to degenerative joint disease, and diabetes mellitus.
机译:主要抑郁症以及其他抑郁症,通常是与其他医学疾病,特别是慢性和全身性医学疾病的混合性。疾病的共同发生是如此普遍,即它挑战我们对合并症的含义以及我们对整齐单独分开的精神病和医疗疾病的愿望的概念。身体疾病症状与主要抑郁症的神经抗症状与对身体疾病的初始规范情绪反应之间的重叠增加了对医学生病的准确诊断和及时治疗抑郁症的挑战。我们审查了抑郁症合并症的文献和各种医学疾病,包括诊断和治疗方法。医疗病患者的主要抑郁症的差异诊断应包括谵妄和药物诱导的症状。我们建议主要抑郁症本身可以最好地概念化为其病理生理学与其他全身医疗疾病重叠的系统性疾病。医疗疾病主要抑郁症的初始治疗策略就像是一般人群的抑郁症;然而,可康的医疗疾病可能会干扰缓解。为了说明这些要点,我们描述了在本综述中涵盖的临床特征的患者,患有主要抑郁症以及几种慢性疾病,包括过敏肺炎,多发性硬化,由于退行性关节疾病,糖尿病患者。

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