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首页> 外文期刊>Psychosomatics >Liver Transplant Recipients Older Than 60 Years Show Executive and Memory Function Improvement Comparable to Younger Recipients
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Liver Transplant Recipients Older Than 60 Years Show Executive and Memory Function Improvement Comparable to Younger Recipients

机译：60岁以上的肝移植受访者表现出执行和记忆功能的改进与年轻接受者相当

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Background: Increasing numbers of patients over the age of 60 are undergoing liver transplantation. Objective: We sought to determine whether age or clinical morbidities were associated with pre- and post-transplant executive and memory performance using the Brief Test of Adult Cognition by Telephone (BTACT). Methods: Participants included 36 recipients with n = 20 in the older group (>60 y) and n = 16 in the younger group (<= 60 years). The BTACT was administered an average of 3 months before transplant, and at follow-up post-transplant intervals of 3, 6, and 9 months. BTACT composite scores for memory and executive function with age and education norms were obtained. Results: Older recipients were more likely to have hepatocellular carcinoma, a lower biological MELD score at transplant, less cellular rejection, and fewer post-operative hospital days. Older and younger recipients showed comparable pre-transplant executive and memory function and comparable post-transplant improvement. Both older and younger patients showed statistically significant improvement in executive function scores at 3 months post-transplant and maintained improvement at 6 and 9 months. Memory function improved significantly in older patients by 6 months post-transplant but did not improve significantly in the younger group. Conclusion: Older liver transplant recipients were more likely to have hepatocellular carcinoma and a lower biological MELD score than younger recipients, but both age groups showed comparable pre-transplant cognitive performance and post-transplant cognitive improvement. Additionally, a normed telephone test can be used to effectively screen and track executive and memory function post-transplant.
机译：背景：60岁以上的患者越来越多的患者正在进行肝移植。目的：我们试图确定是否使用电话（BTACT）的成人认知的简要考验与移植前的年龄或临床病症和内存绩效有关。方法：参与者在较旧的组（> 60 y）中包含36名，n = 20），较年轻群体中的n = 16（<= 60岁）。在移植前平均施用BTACT 3个月，随访后移植后3,6和9个月。获得了记忆的BTACT综合评分和年龄和教育规范的执行功能。结果：较旧的受体更容易患有肝细胞癌，在移植，较少的细胞排斥和术后医院的较少的生物混合评分下降。年龄较大的接受者显示出可比的移植前进的执行和记忆功能以及可比移植后的改进。老年人和年轻患者均在移植后3个月内表现出统计上显着改善，并在6和9个月内保持改善。在移植后6个月内患者的记忆功能显着改善，但在较年轻的群体中没有显着提高。结论：较旧的肝脏移植受者更容易患有肝细胞癌和低于年轻受体的生物融合得分，但两龄龄群体显示出可比的移植前的认知性能和移植后的认知改善。此外，规范的电话测试可用于有效筛选和跟踪移植后的执行和记忆功能。

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