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首页> 外文期刊>Ultrasound in Medicine and Biology >THE PROTEOMIC EFFECTS OF PULSED FOCUSED ULTRASOUND ON TUMOR MICROENVIRONMENTS OF MURINE MELANOMA AND BREAST CANCER MODELS
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THE PROTEOMIC EFFECTS OF PULSED FOCUSED ULTRASOUND ON TUMOR MICROENVIRONMENTS OF MURINE MELANOMA AND BREAST CANCER MODELS

机译：脉冲聚焦超声对鼠黑素瘤和乳腺癌模型肿瘤微环境的蛋白质组学作用

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摘要

Non-ablative pulsed focused ultrasound (pFUS) targets non-thermal forces that activate local molecular and cellular immune responses. Optimal parameters to stimulate immunotherapeutic tumor microenvironments (TME) and responses in different tumor types remain uninvestigated. Flank B16 murine melanoma and 4T1 breast tumors received 1 MHz pFUS at 1-8 MPa peak negative pressures (PNP) and were analyzed 24 hr post-sonication. Necrosis or hemorrhage were unaltered in both tumors, but pFUS induced DNA strand breaks in tumor cells at PNP >= 6 MPa. pFUS at >4 MPa suppressed anti-inflammatory cytokines in B16 tumors. pFUS to 4T1 tumors decreased anti-inflammatory cytokines and increased pro-inflammatory cytokines and cell adhesion molecules. pFUS at 6 MPa increased calreticulin and alterations in check-point proteins along with tumoral and splenic immune cell changes that could be consistent with a shift towards an anti-TME. pFUS-induced TME alterations shows promise in generating anti-tumor immune responses, but non-uniform responses between tumor types require additional investigation to assess pFUS as a suitable anti-tumor therapy. Published by Elsevier Inc. on behalf of World Federation for Ultrasound in Medicine & Biology.
机译：非烧蚀脉冲聚焦超声（PFU）靶向激活局部分子和细胞免疫应答的非热力。刺激免疫治疗性肿瘤微环境（TME）和不同肿瘤类型的反应的最佳参数仍未取消。侧翼B16鼠黑素瘤和4T1乳腺肿瘤在1-8MPa峰值负压（PNP）下接受1MHz PFU，并分析了24小时后超声处理。在两个肿瘤中未妨碍坏死或出血，但PFU诱导的DNA链在PNP> = 6MPa的肿瘤细胞中断裂。 PFU> 4MPa抑制B16肿瘤中的抗炎细胞因子。 PFU至4T1肿瘤降低抗炎细胞因子和增加的促炎细胞因子和细胞粘附分子。 PFU在6MPa增加钙霉素和检查点蛋白的改变以及肿瘤和脾脏免疫细胞的变化，其可以与抗TME的转变一致。 PFU诱导的TME改变显示出在产生抗肿瘤免疫应答时的承诺，但肿瘤类型之间的不均匀反应需要额外的调查来评估PFU作为合适的抗肿瘤治疗。由elsevier Inc.发布的Moribo Federation在医学和生物学中的超声波联合会。

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