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首页> 外文期刊>Pathology Research and Practice >Expression and significance of CD47, PD1 and PDL1 in T-cell acute lymphoblastic lymphoma/leukemia
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Expression and significance of CD47, PD1 and PDL1 in T-cell acute lymphoblastic lymphoma/leukemia

机译：CD47，PD1和PDL1在T细胞急性淋巴细胞淋巴瘤/白血病中的表达及意义

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摘要

Although dose intensification strategies achieve a favorable prognosis for pediatric patients of T-lmphoblastic lymphoma/leukemia (T-LBL/ALL), numerous side effects have been followed. Molecular targeted therapies will be needed to optimize the current treatment strategy for T-LBL/ALL. The aim of this study was to analyse expression and significance of CD47, PD1 and PDL1 in. T-LBL/ALL. We performed immunohistochemistry staining and real time fluorescence quantitative PCR (qRT-PCR) on FFPE tissues. Immunohistochemistry results showed that the high expression rate of CD47 protein was 46.4% (26/56) and the positive expression rate of PDL1 protein was 37.5% (21/56). PD1 expression was observed in tumor infiltrating lymphocytes in approximately 20% of T-LBL/ALL patients, but not expressed on tumor cells of T-LBL/ALL. And the results of qRT-PCR showed that the relative expression levels of CD47, PDL1 and PD1 mRNA in 56 cases of T-LBL/ALL were significantly higher than those in control group (6.915 vs 4.050, 12.255 vs 2.575, 37.990 vs 3.615), and the differences were all statistically significant (p all = M) of CD47 and PDL1 mRNA were higher than in patients with low expression ( = M) of CD47 and PDL1 protein were lower than in patients with low expression ( 25 years old. Multivariate Cox regression analysis showed that the high expression of CD47 and PDL1 protein were independent prognostic factors (both p < 0.05). In a word, PD1/PDL1 and CD47 may be involved in the disease progression and prognosis of T-LBL/ALL, and detection and targeting of CD47 and PD1/PDL1 may provide a rational basis to for treatment of T-LBL/ALL.
机译：虽然剂量强化策略对T-LMPhoblas弹性淋巴瘤/白血病（T-LBL /全部）的儿科患者来说，达到了有利预后，但已经遵循了许多副作用。需要分子靶向疗法来优化T-LBL /全部的当前治疗策略。本研究的目的是分析CD47，PD1和PDL1的表达和意义。T-LBL /全部。我们对FFPE组织进行免疫组织化学染色和实时荧光定量PCR（QRT-PCR）。免疫组织化学结果表明，CD47蛋白的高表达率为46.4％（26/56），PDL1蛋白的阳性表达率为37.5％（21/56）。在肿瘤浸润淋巴细胞中观察到PD1表达，约20％的T-LBL /所有患者，但在T-LBL /全部的肿瘤细胞上表达。 QRT-PCR的结果表明，在56例T-LBL /所有情况下CD47，PDL1和PD1 mRNA的相对表达水平显着高于对照组（6.915 VS 4.050,12.255 VS 2.575,37.990 VS 3.615） ，并且差异是CD47和PDL1 mRNA的统计学意义（P all = M）高于CD47的低表达（= M）的患者，PDL1蛋白低于表达低表达（25岁）。多元化COX回归分析表明，CD47和PDL1蛋白的高表达是独立的预后因子（P <0.05）。在一个单词中，PD1 / PDL1和CD47可以参与T-LBL /全部的疾病进展和预后，以及CD47和PD1 / PDL1的检测和靶向可以为用于治疗T-LBL /全部提供合理的基础。

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  • 来源
    《Pathology Research and Practice》 |2019年第2期|共7页
  • 作者

    Yang Kun; Xu Jing; Liu Qinghang; Li Jing; Xi Yanfeng;

  • 作者单位

    Shanxi Med Univ Dept Pathol Taiyuan Shanxi Peoples R China;

    Shanxi Med Univ Dept Pathol Taiyuan Shanxi Peoples R China;

    Zhengzhou Univ Affiliated Hosp 1 Dept Thorac Surg Zhengzhou Henan Peoples R China;

    Shanxi Canc Hosp Dept Pathol 3 Zhigongxin St Taiyuan 030013 Shanxi Peoples R China;

    Shanxi Canc Hosp Dept Pathol 3 Zhigongxin St Taiyuan 030013 Shanxi Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 病理学;
  • 关键词

    Lymphoma; T-cell; Leukemia; PD1; PDL1; CD47;

    机译：淋巴瘤;T细胞;白血病;PD1;PDL1;CD47;

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