Immunohistochemical analysis of c-erbB-2, Bcl-2, p53, p21(WAF1/Cip1), p63 and Ki-67 expression in hydatidiform moles

Missaoui Nabiha; Landolsi Hanene; Mestiri Sarra; Essakly Ahlem; Abdessayed Nihed; Hmissa Sihem; Mokni Moncef; Yacoubi Mohamed Tahar

首页> 外文期刊>Pathology Research and Practice >Immunohistochemical analysis of c-erbB-2, Bcl-2, p53, p21(WAF1/Cip1), p63 and Ki-67 expression in hydatidiform moles

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Immunohistochemical analysis of c-erbB-2, Bcl-2, p53, p21(WAF1/Cip1), p63 and Ki-67 expression in hydatidiform moles

机译：C-ERBB-2，BCL-2，P53，P21（WAF1 / CIP1），P63和KI-67中的无菌状钼的免疫组织化学分析

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Hydatidiform moles (HM) are characterized by an abnormal proliferating trophoblast with a potential for a malignant transformation. Similar to other human tumors, trophoblastic pathogenesis is likely a multistep process involving several molecular and genetic alterations. The study was performed to investigate the expression patterns of c-erbB-2 and Bcl-2 oncoproteins, p53, p21(WAF1/CIP1) and p63 tumor suppressor proteins and Ki-67 cell proliferation marker in HM.

机译：瓦湿摩尔（HM）的特征在于异常增殖的滋养细胞，其具有恶性转化的潜力。类似于其他人类肿瘤，滋养细胞发病机理可能是多级过程，涉及几种分子和遗传改变。进行研究以研究C-ERBB-2和BCL-2癌蛋白，P53，P21（WAF1 / CIP1）和P63肿瘤抑制蛋白和KI-67细胞增殖标记物的表达模式。

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来源
《Pathology Research and Practice》 |2019年第3期|共7页
作者
Missaoui Nabiha; Landolsi Hanene; Mestiri Sarra; Essakly Ahlem; Abdessayed Nihed; Hmissa Sihem; Mokni Moncef; Yacoubi Mohamed Tahar;
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作者单位

Univ Sousse Res Unit UR14ES17 Canc Epidemiol &

Cytopathol Tunisian Ctr Med Fac Sousse Sousse;

Univ Sousse Res Unit UR14ES17 Canc Epidemiol &

Cytopathol Tunisian Ctr Med Fac Sousse Sousse;

Farhet Hached Hosp Pathol Dept Sousse 4000 Tunisia;

Univ Sousse Med Fac Sousse Sousse 4000 Tunisia;

Farhet Hached Hosp Pathol Dept Sousse 4000 Tunisia;

Univ Sousse Res Unit UR14ES17 Canc Epidemiol &

Cytopathol Tunisian Ctr Med Fac Sousse Sousse;

Farhet Hached Hosp Pathol Dept Sousse 4000 Tunisia;

Farhet Hached Hosp Pathol Dept Sousse 4000 Tunisia;

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原文格式 PDF
正文语种 eng
中图分类病理学;
关键词
Complete hydatidiform mole; Partial hydatidiform mole; Hydropic abortion; Bcl-2; p53; p63; Ki-67;

机译：完整的瓦尔膜;部分含者;液体流产;Bcl-2;p53;p63;ki-67;

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1. Immunohistochemical analysis of c-erbB-2, Bcl-2, p53, p21(WAF1/Cip1), p63 and Ki-67 expression in hydatidiform moles [J] . Missaoui Nabiha, Landolsi Hanene, Mestiri Sarra, Pathology Research and Practice . 2019,第3期

机译：C-ERBB-2，BCL-2，P53，P21（WAF1 / CIP1），P63和KI-67中的无菌状钼的免疫组织化学分析
2. Protein expression of p53, p21 (WAF1/CIP1), bcl-2, Bax, cyclin D1 and pRb in human colon carcinomas. [J] . Bukholm IK, Nesland JM Virchows Archiv: an international journal of pathology . 2000,第3期

机译：p53，p21（WAF1 / CIP1），bcl-2，Bax，cyclin D1和pRb在人结肠癌中的蛋白表达。
3. Expression of p21WAF1/CIP1, p53, bcl-2 and Ki-67 in venous leg ulcers with and without squamous cell carcinoma. [J] . Baldursson B, Syrjanen S, Beitner H Acta Dermato-Venereologica . 2000,第4期

机译：p21WAF1 / CIP1，p53，bcl-2和Ki-67在有或没有鳞状细胞癌的静脉小腿溃疡中的表达。
4. Actinobacillus actinomycetemcomitans Cytolethan Distending Toxin Induces p53-independent Expression of p21 ~CIP/WAF1 and G2/M Cell Cycle Arrest in Plasmacytic Cells [C] . T. Sato, T. Koseki, K. Yamato, International Symposium on PPARs : From Basic Science to Clinical Applications . 2002

机译：Actinobacillus actinomycetemcolans cytolethan扩张毒素诱导p21〜CIP / WAF1和G2 / M细胞循环抑制的P53无关表达
5. The role and regulation of p21(WAF1/CIP1) in myelopoiesis. [D] . Ghanem, Louis R. 2005

机译：p21（WAF1 / CIP1）在骨髓生成中的作用和调控。
6. Overexpression of HMGB1 in melanoma predicts patient survival and suppression of HMGB1 induces cell cycle arrest and senescence in association with p21 (Waf1/Cip1) up-regulation via a p53-independent Sp1-dependent pathway [O] . Qingling Li, Jie Li, Ting Wen, 2014

机译：HMGB1在黑色素瘤中的过表达预示了患者的生存而HMGB1的抑制通过独立于p53Sp1的途径与p21（Waf1 / Cip1）上调相关诱导了细胞周期停滞和衰老。
7. Analysis of the immunohistochemical expressions of p53, bcl-2 and Ki-67 in colorectal adenocarcinoma and their correlations with the prognostic factors Análise das expressões imunoistoquímicas da p53, bcl-2 e Ki-67 no adenocarcinoma colorretal e suas correlações com os fatores prognósticos [O] . Hunaldo Lima de Menezes, Mário Jorge Jucá, Edmundo Guilherme de A. Gomes, 2010

机译：p53，bcl-2和Ki-67免疫组化在结直肠腺癌中的表达及其与预后因素的相关性分析p53，bcl-2和Ki-67免疫组化在结直肠腺癌中的表达及其与预后因素的相关性

Immunohistochemical analysis of c-erbB-2, Bcl-2, p53, p21(WAF1/Cip1), p63 and Ki-67 expression in hydatidiform moles

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