Expression of p21WAF1/CIP1, p53, bcl-2 and Ki-67 in venous leg ulcers with and without squamous cell carcinoma.

Baldursson B; Syrjanen S; Beitner H

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Expression of p21WAF1/CIP1, p53, bcl-2 and Ki-67 in venous leg ulcers with and without squamous cell carcinoma.

机译：p21WAF1 / CIP1，p53，bcl-2和Ki-67在有或没有鳞状细胞癌的静脉小腿溃疡中的表达。

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In order to gain understanding of the cellular mechanisms of malignant transformation in chronic venous leg ulcers, we analysed by immunohistochemistry the presence of p21, p53, bcl-2 and Ki-67 in ulcers with and without squamous cell carcinoma. The material consisted of 41 archived histopathological samples from 33 patients with chronic venous leg ulcers and 28 samples from 21 patients suffering from squamous cell carcinoma in chronic venous leg ulcers. All samples derived from the chronic ulcers were negative for p53, p21 and bcl-2. Cells positive for Ki-67 were seen in certain ulcer areas. In the cancers, 14 samples showed immunopositivity for p53 and 22 samples were positive for p21, with expression mainly in the suprabasal layer. Expression of p21 seemed independent of p53. None of the samples was bcl-2-positive. Ki-67 was positive with basal expression in 16/28 of the tumour samples, 15 of which also expressed p21. There was no perilesional p53 or p21 activity in the cancer samples. The results regarding perilesional expression are different from those reported in UV-induced squamous cell carcinomas and probably reflect a different carcinogen.

机译：为了了解慢性静脉曲张性溃疡的恶性转化的细胞机制，我们通过免疫组织化学分析了有或无鳞状细胞癌的溃疡中p21，p53，bcl-2和Ki-67的存在。该材料包括来自33例慢性静脉曲张性溃疡患者的41份组织病理学样本和来自21例慢性静脉曲张性溃疡鳞状细胞癌患者的28个样本。来自慢性溃疡的所有样品的p53，p21和bcl-2均为阴性。在某些溃疡区域可观察到Ki-67阳性细胞。在癌症中，有14个样品显示出对p53的免疫阳性，而22个样品显示出对p21呈阳性，主要在上基底层中表达。 p21的表达似乎独立于p53。所有样品都不是bcl-2阳性的。 Ki-67在16/28个肿瘤样品中呈基础表达阳性，其中15个也表达p21。在癌症样品中没有病灶周围的p53或p21活性。关于病灶周围表达的结果与紫外线诱导的鳞状细胞癌中报道的结果不同，并且可能反映出不同的致癌物。

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《Acta Dermato-Venereologica》 |2000年第4期|共5页
作者
Baldursson B; Syrjanen S; Beitner H;
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正文语种 eng
中图分类皮肤病学与性病学;
关键词
Carcinoma; Squamous Cell; Cyclins; Ki-67 Antigen; Leg Ulcer; Protein p53; 癌; 鳞状细胞; 细胞周期蛋白类; Ki-67抗原; 腿溃疡; 蛋白质P53; 原致癌基因蛋白质 c-bcl-2;

机译：Carcinoma;Squamous Cell;Cyclins;Ki-67 Antigen;Leg Ulcer;Protein p53;癌;鳞状细胞;细胞周期蛋白类;Ki-67抗原;腿溃疡;蛋白质P53;原致癌基因蛋白质 c-bcl-2;

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1. Expression of p21WAF1/CIP1, p53, bcl-2 and Ki-67 in venous leg ulcers with and without squamous cell carcinoma. [J] . Baldursson B, Syrjanen S, Beitner H Acta Dermato-Venereologica . 2000,第4期

机译：p21WAF1 / CIP1，p53，bcl-2和Ki-67在有或没有鳞状细胞癌的静脉小腿溃疡中的表达。
2. Expression patterns of cyclins D1, E and cyclin-dependent kinase inhibitors p21waf1/cip1, p27kip1 in colorectal carcinoma: correlation with other cell cycle regulators (pRb, p53 and Ki-67 and PCNA) and clinicopathological features. [J] . Ioachim E International journal of clinical practice . 2008,第11期

机译：大肠癌中细胞周期蛋白D1，E和细胞周期蛋白依赖性激酶抑制剂p21waf1 / cip1，p27kip1的表达模式：与其他细胞周期调节因子（pRb，p53和Ki-67和PCNA）的关系和临床病理特征。
3. p21WAF1/Cip1 expression is associated with cell differentiation but not with p53 mutations in squamous cell carcinomas of the larynx. [J] . Nadal A, Jares P, Cazorla M, Journal of Pathology: Journal of the Pathological Society of Great Britain and Ireland . 1997,第2期

机译：在喉鳞状细胞癌中，p21WAF1 / Cip1表达与细胞分化有关，但与p53突变无关。
4. Effects of Bcl-2, bax and p53 Gene Protein Expressions in Gastric Cancer Tissue on the Apoptosis of Cancer Cells [C] . Lei Zhang, Dapeng Li, Guannan Lu International Conference on Applied Mechanics, Materials and Manufacturing . 2013

机译：Bcl-2，Bax和P53基因蛋白表达在胃癌组织对癌细胞凋亡的影响
5. The antiproliferative effects of sodium butyrate on human colonic adenocarcinoma cells: Chromatin remodeling on p21WAF1/CIP1 promoter. [D] . Kobayashi, Hanako. 2003

机译：丁酸钠对人结肠腺癌细胞的抗增殖作用：p21WAF1 / CIP1启动子上的染色质重塑。
6. Correlation among 16 biological factors p53 p21waf1 MIB-1 (Ki-67) p16INK4A cyclin D1 E-cadherin Bcl-2 TNF-α NF-κB TGF-β MMP-7 COX-2 EGFR HER2eu ER and HIF-1α and clinical outcomes following curative chemoradiation therapy in 10 patients with esophageal squamous cell carcinoma [O] . SHINO SHIBATA-KOBAYASHI, HIDEOMI YAMASHITA, KAE OKUMA, -1

机译：16种生物学因子p53p21waf1MIB-1（Ki-67）p16INK4Acyclin D1E-cadherinBcl-2TNF-αNF-κBTGF-βMMP-7COX- 2EGFRHER2 / neuER和HIF-1α与10例食管鳞癌根治性化学放射治疗后的临床结局
7. Effect of Valproic Acid on the Class I Histone Deacetylase 1, 2 and 3, Tumor Suppressor Genes p21WAF1/CIP1 and p53, and Intrinsic Mitochondrial Apoptotic Pathway, Pro- (Bax, Bak, and Bim) and anti- (Bcl-2, Bcl-xL, and Mcl-1) Apoptotic Genes Expression, Cell Viability, and Apoptosis Induction in Hepatocellular Carcinoma HepG2 Cell Line [O] . Massumeh Sanaei, Fraidoon Kavoosi 2021

机译：丙戊酸对I类组蛋白脱乙酰化酶1,2和3，肿瘤抑制基因P21WAF1 / CIP1和P53，以及内在线粒体凋亡途径，Pro-（Bax，Bak和Bim）和抗 - （Bcl-2，Bcl -XL和MCL-1）肝细胞癌HepG2细胞中凋亡基因表达，细胞活力和凋亡诱导

Expression of p21WAF1/CIP1, p53, bcl-2 and Ki-67 in venous leg ulcers with and without squamous cell carcinoma.

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