...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Pathology: Journal of the Pathological Society of Great Britain and Ireland >p21WAF1/Cip1 expression is associated with cell differentiation but not with p53 mutations in squamous cell carcinomas of the larynx.
【24h】

p21WAF1/Cip1 expression is associated with cell differentiation but not with p53 mutations in squamous cell carcinomas of the larynx.

机译：在喉鳞状细胞癌中，p21WAF1 / Cip1表达与细胞分化有关，但与p53突变无关。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

p21WAF1/Cip1 is a recently identified gene involved in cell cycle regulation through cyclin-CDK-complex inhibition. The expression of this gene in several cell lines seems to be induced by wild-type, but not mutant, p53. p21WAF1/Cip1 expression has been studied at both mRNA and protein levels in a series of 49 normal mucosae and squamous cell carcinomas of the larynx. A significant association was found between mRNA and protein expression in tumours (P < 0.0001). p21WAF1/Cip1 expression was strongly associated with squamous cell differentiation of carcinomas, because six of seven (86 per cent) undifferentiated carcinomas (grade 4) showed very low levels of p21WAF1/Cip1 expression, whereas 41 out of 42 (98 per cent) carcinomas with squamous cell differentiation (grades 1-3) had normal or high levels of p21WAF1/Cip1 expression (P < 0.0001). In addition, p21WAF1/Cip1 expression was topologically related to the squamous differentiation of tumour cells with a distribution similar to that seen in normal squamous epithelium. No correlation was found between p21WAF1/Cip1 expression and the global S-phase of the carcinomas. p53 mutations (exons 5-9) were found in ten carcinomas with p21WAF1/Cip1 expression, but no p53 mutations were detected in three p21WAF1/Cip1-negative tumours. In conclusion, p21WAF1/Cip1 expression is frequently upregulated in squamous cell carcinomas of the larynx and is associated with tumour cell differentiation. p21WAF1/Cip1 expression in these tumours is independent of p53 gene mutations.
机译：p21WAF1 / Cip1是最近发现的通过细胞周期蛋白-CDK-复合物抑制作用参与细胞周期调控的基因。该基因在几种细胞系中的表达似乎是由野生型而非突变型p53诱导的。在一系列49例喉部正常粘膜和鳞状细胞癌中，已经研究了p21WAF1 / Cip1在mRNA和蛋白水平上的表达。发现肿瘤中的mRNA和蛋白质表达之间存在显着关联（P <0.0001）。 p21WAF1 / Cip1表达与癌的鳞状细胞分化密切相关，因为七种未分化癌（4级）中的六种（86％）显示出非常低的p21WAF1 / Cip1表达水平，而42种癌（41％）中有41种表达（21％）鳞状细胞分化（1-3级）的患者p21WAF1 / Cip1表达水平正常或较高（P <0.0001）。此外，p21WAF1 / Cip1的表达与肿瘤细胞的鳞状细胞分化有关，其分布与正常鳞状上皮细胞相似。在p21WAF1 / Cip1表达与癌症的整体S期之间未发现相关性。在十个表达p21WAF1 / Cip1的癌中发现了p53突变（外显子5-9），但在三个p21WAF1 / Cip1阴性肿瘤中未检测到p53突变。总之，p21WAF1 / Cip1表达在喉鳞状细胞癌中经常被上调，并且与肿瘤细胞分化有关。这些肿瘤中的p21WAF1 / Cip1表达与p53基因突变无关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号