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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Changes in Morbidity, Physical Fitness, and Perceived Quality of Life among Schoolchildren following Four Years of Different Mass Drug Administration Strategies against Schistosoma mansoni Infection in Mwanza Region, Northwestern Tanzania
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Changes in Morbidity, Physical Fitness, and Perceived Quality of Life among Schoolchildren following Four Years of Different Mass Drug Administration Strategies against Schistosoma mansoni Infection in Mwanza Region, Northwestern Tanzania

机译：在坦桑尼亚西北部Mwanza地区的不同大众药物管理策略中，在不同大规模药物管理策略中，在不同大规模药物管理策略中的发病率，身体健康和感知生活质量的变化

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摘要

Schistosoma mansoni infection negatively impacts childrens physical health and may influence general well-being. Schistosomiasis control programs aim at reducing morbidity through mass drug administration (MDA). This study aimed to compare morbidity markers between two cohorts of Tanzanian schoolchildren with initial high prevalence of S. mansoni infection. One cohort (N = 254 at baseline) received annual MDA for 4 years using community-wide treatment (CWT). The second cohort (N = 318 at baseline) received school-based treatment (SBT) every other year for 4 years. At year 5, the CWT cohort and the SBT cohort were reduced to 153 and 221 children, respectively. The characteristics of the 198 children lost to follow-up did not differ at baseline from those who were examined in year 5. Schistosoma mansoni infection, hemoglobin (Hb) and anemia, physical fitness, and perceived quality of life were investigated at baseline, year 3, and year 5, whereas liver and spleen pathology (ultrasound) were investigated only at baseline and year 5. Cohorts were compared using two-way mixed-model analysis of variance (ANOVA). Both treatment regimens significantly decreased individual-level mean intensity of S. mansoni infection, anemia, and hepatomegaly, and increased Hb levels after 5 years. Hepatomegaly was the only parameter affected by the treatment regimen as the CWT approach reduced the percentage of individuals with hepatomegaly significantly more than the SBT approach. Both treatment regimens led to reduced physical fitness at year 5 compared with baseline. The modest impact of the two control strategies are probably due to initial low intensity of infection, ensuring low level of schistosomiasis-related morbidity.
机译：Schistosoma Mansoni感染对儿童身体健康产生负面影响，可能影响一般福祉。血吸虫病控制计划旨在通过大规模药物管理（MDA）降低发病率。本研究旨在比较坦桑尼亚小学生两位群组之间的发病率标志，其初步普遍存在的S. Mansoni感染。一个队列（基线N = 254）使用社区范围的治疗（CWT）收到了4年的年度MDA。第二个队列（基线N = 318）每隔一年收到基于学校的待遇（SBT）4年。 5，CWT队列和SBT队列分别减少到153和221名儿童。 198名儿童的特点在于在第5岁审查的那些中的基线上没有区别。血吸虫麦森感染，血红蛋白（HB）和贫血，身体健康和生活质量，年份3年和5年，而肝脏和脾脏病理学（超声）仅在基线和第5和第5次进行了研究。使用双向混合模型分析（ANOVA）进行比较队列。治疗方案均显着降低了S.Mansoni感染，贫血和肝肿大的个体级别平均强度，5年后的HB水平增加。肝肿大是受治疗方案影响的唯一参数，因为CWT方法减少了肝肿大的个体的百分比明显超过SBT方法。与基线相比，两种治疗方案都会导致5年级的身体健康。两种控制策略的适度影响可能是由于初始感染强度，确保血吸虫病相关的发病率低。

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