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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Discovering, Defining, and Summarizing Persistent Hotspots in SCORE Studies
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Discovering, Defining, and Summarizing Persistent Hotspots in SCORE Studies

机译:在评分研究中发现,定义和总结持久热点

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摘要

The Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) conducted large field studies on schistosomiasis control and elimination in Africa. All of these studies, carried out in low-, moderate-, and high-prevalence areas, resulted in a reduction in prevalence and intensity of Schistosoma infection after repeated mass drug administration (MDA). However, in all studies, there were locations that experienced minimal or no decline or even increased in prevalence and/or intensity. These areas are termed persistent hotspots (PHS). In SCORE studies in mediumto high-prevalence areas, at least 30% of study villages were PHS. There was no consistent relationship between PHS and the type or frequency of intervention, adequacy of reported MDA coverage, and prevalence or intensity of infection at baseline. In a series of small studies, factors that differed between PHS and villages that responded to repeated MDA as expected included sources of water for personal use, sanitation, and hygiene. SCORE studies comparing PHS with villages that responded to MDA suggest the potential for PHS to be identified after a few years of MDA. However, additional studies in different social-ecological settings are needed to develop generalizable approaches that program managers can use to identify and address PHS. This is essential if goals for schistosomiasis control and elimination are to be achieved.
机译:用于操作研究和评估的血吸虫病联盟(得分)对非洲的血吸虫病控制和消除进行了大型现场研究。在低,中等和高流行区域进行的所有这些研究导致反复大规模药物管理(MDA)后血吸虫瘤感染的患病率和强度降低。然而,在所有研究中,有些地方经历了最小或没有下降或甚至患病率和/或强度的增加。这些区域被称为持久热点(pH)。在媒介中的患者中学研究中,至少30%的研究村是pH。 PHS与介入的类型或频率之间没有一致的关系,报告的MDA覆盖率的充分性以及基线感染的患病率或感染强度。在一系列的小型研究中,对重复MDA的PHS和村庄之间存在不同的因素包括用于个人使用,卫生和卫生的水源。评分研究与患有MDA的村庄的pHS比较,表明在几年的MDA后才能确定pHS的可能性。然而,需要在不同的社会生态环境中进行额外的研究来开发普遍的方法,程序管理人员可以用来识别和解决pHS。如果要实现血吸虫病控制和消除的目标,这是必不可少的。

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