Detection of Taenia solium DNA in the Urine of Neurocysticercosis Patients

Toribio Luz; Romano Miryam; Scott Alan L.; Gonzales Isidro; Garcia Hector H.; Shiff Clive; Gilman Robert H.; Gonzalez Armando E.; Tsang Victor C. W.; Rodriguez Silvia; Gonzalez Isidro; Saavedra Herbert; Martinez Manuel; Verastegui Manuela; Zimic Mirko; Bustos Javier; Santivanez Saul; Mayta Holger; Castillo Yesenia; Pajuelo Monica; Arroyo Gianfranco; Lopez Maria T.; Gomez Luis; Gavidia Cesar M.; Moyano Luz M.; Gamboa Ricardo; Muro Claudio; Vichez Percy; Handali Sukwan; Noh John; Nash Theodore E.; Mahanty Siddhartha; Friedland Jon

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Detection of Taenia solium DNA in the Urine of Neurocysticercosis Patients

机译：检测神经细胞病患者尿液中的绦虫源DNA

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Neurocysticercosis (NCC), caused by Taenia solium larvae that reside in the central nervous system, results in serious public health and medical issues in many regions of the world. Current diagnosis of NCC is complex requiring both serology and costly neuroimaging of parasitic cysts in the brain. This diagnostic pipeline can be problematic in resource-constrained settings. There is an unmet need for a highly sensitive and clinically informative diagnostic test to complement the present diagnostic approaches. Here, we report that T. solium-derived cell-free DNA is readily detectable in the urine of patients with the subarachnoid and parenchymal forms of NCC, and discuss the potential utility of this approach in enhancing and refining T. solium diagnostics.

机译：由位于中枢神经系统中的绦虫源幼虫引起的神经细胞术（NCC）导致世界许多地区的严重公共卫生和医疗问题。目前对NCC的诊断是复杂的，需要大脑中寄生虫囊肿的血清学和昂贵的神经模仿。此诊断管道在资源受限设置中可能存在问题。对高度敏感和临床信息丰富的诊断测试有一个未满足的需要，以补充当前的诊断方法。在此，我们报告说，在蛛网膜下腔和实质形式的NCC患者的尿液中，易于检测到溶胶衍生的细胞DNA，并讨论这种方法在增强和精炼棒诊断中的潜在效用。

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来源
《The American Journal of Tropical Medicine and Hygiene》 |2019年第2期|共3页
作者
Toribio Luz; Romano Miryam; Scott Alan L.; Gonzales Isidro; Garcia Hector H.; Shiff Clive; Gilman Robert H.; Gonzalez Armando E.; Tsang Victor C. W.; Rodriguez Silvia; Gonzalez Isidro; Saavedra Herbert; Martinez Manuel; Verastegui Manuela; Zimic Mirko; Bustos Javier; Santivanez Saul; Mayta Holger; Castillo Yesenia; Pajuelo Monica; Arroyo Gianfranco; Lopez Maria T.; Gomez Luis; Gavidia Cesar M.; Moyano Luz M.; Gamboa Ricardo; Muro Claudio; Vichez Percy; Handali Sukwan; Noh John; Nash Theodore E.; Mahanty Siddhartha; Friedland Jon;
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作者单位

Univ Peruana Cayetano Heredia Ctr Global Hlth Lima Peru;

Johns Hopkins Univ Bloomberg Sch Publ Hlth W Harry Feinstone Dept Mol Microbiol &

Immunol;

Johns Hopkins Univ Bloomberg Sch Publ Hlth W Harry Feinstone Dept Mol Microbiol &

Immunol;

Inst Nacl Ciencias Neurol Cysticercosis Unit Lima Peru;

Univ Peruana Cayetano Heredia Ctr Global Hlth Lima Peru;

Johns Hopkins Univ Bloomberg Sch Publ Hlth W Harry Feinstone Dept Mol Microbiol &

Immunol;

Coordinat Board Nairobi Kenya;

Coordinat Board Nairobi Kenya;

Coordinat Board Nairobi Kenya;

Inst Nacl Ciencias Neurol Lima Peru;

Inst Nacl Ciencias Neurol Lima Peru;

Inst Nacl Ciencias Neurol Lima Peru;

Inst Nacl Ciencias Neurol Lima Peru;

Univ Peruana Cayetano Heredia Lima Peru;

Univ Peruana Cayetano Heredia Lima Peru;

Univ Peruana Cayetano Heredia Lima Peru;

Univ Peruana Cayetano Heredia Lima Peru;

Univ Peruana Cayetano Heredia Lima Peru;

Univ Peruana Cayetano Heredia Lima Peru;

Univ Peruana Cayetano Heredia Lima Peru;

Univ Peruana Cayetano Heredia Lima Peru;

Univ Nacl Mayor San Marcos Sch Vet Med Lima Peru;

Univ Nacl Mayor San Marcos Sch Vet Med Lima Peru;

Univ Nacl Mayor San Marcos Sch Vet Med Lima Peru;

Cysticercosis Eliminat Program Tumbes Peru;

Cysticercosis Eliminat Program Tumbes Peru;

Cysticercosis Eliminat Program Tumbes Peru;

Cysticercosis Eliminat Program Tumbes Peru;

Ctr Dis Control Atlanta GA 30333 USA;

Ctr Dis Control Atlanta GA 30333 USA;

NIAID NIH 9000 Rockville Pike Bethesda MD 20892 USA;

NIAID NIH 9000 Rockville Pike Bethesda MD 20892 USA;

Imperial Coll London England;

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正文语种 eng
中图分类地方病学;
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专利

1. Detection of Taenia solium DNA in the Urine of Neurocysticercosis Patients [J] . Toribio Luz, Romano Miryam, Scott Alan L., The American Journal of Tropical Medicine and Hygiene . 2019,第2期

机译：检测神经细胞病患者尿液中的绦虫源DNA
2. Detection of Taenia solium Antigens and Anti–T. solium Antibodies in Paired Serum and Cerebrospinal Fluid Samples from Patients with Intraparenchymal or Extraparenchymal Neurocysticercosis [J] . Silvia Rodriguez12 Pierre Dorny6 Victor C. W. Tsang7 E. Javier Pretell13 Jef Brandt6 Andres G. Lescano4 Armando E. Gonzalez25 Robert H. Gilman238 and Cysticercosis Working Group in Peru123a Journal of Infectious Diseases . 2009,第9期

机译：Ta虫lium抗原和抗T的检测。实质内或实质外神经囊尾osis病患者血清和脑脊液配对样本中的血清抗体
3. Use of Taenia crassiceps Cysticercus Antigen Preparations for Detection of Antibodies in Cerebrospinal Fluid Samples from Patients with Neurocysticercosis (Taenia solium) [J] . Alessandra Xavier Pardini, Regina Helena Peralta, Adelaide José Vaz, Clinical and diagnostic laboratory immunology . 2002,第1期

机译：猪带en虫囊尾er抗原制剂在检测神经囊尾osis病患者脑脊液样品中的抗体的用途
4. The Construction and The Biosafety Research of A DNA Vaccine pPCV-HP Against Taenia solium cysticercosis [C] . Wen-Juan Yao, Xiao-Zhao Deng, Zhen-Yu Diao, International Forum on Progress on Post-Genome Technologies(5'IFPT); 20070910-11; Suzhou(CN) . 2007

机译：DNA疫苗pPCV-HP抗猪带en虫囊尾rc病的构建及生物安全性研究
5. Gamma-delta T lymphocytes: Immunoregulatory and effector functions during murine neurocysticercosis (Taenia solium). [D] . Cardona Bedoya, Astrid Elena. 2002

机译：γ-δT淋巴细胞：鼠神经囊尾rc病（Taenia solium）期间的免疫调节和效应子功能。
6. Detection of Taenia solium DNA in the Urine of Neurocysticercosis Patients [O] . Luz Toribio, Miryam Romano, Alan L. Scott, 2019

机译：神经囊尾osis病患者尿液中Ta虫so虫DNA的检测
7. Detection of Taenia solium antigens and anti-T. solium antibodies in paired serum and cerebrospinal fluid samples from patients with intraparenchymal or extraparenchymal neurocysticercosis [O] . Rodriguez, S., Dorny, P., Tsang, V. C. W., 2009

机译：检测猪带so虫抗原和抗-T。实质内或实质外神经囊虫病患者血清和脑脊液配对样品中的血清抗体

Detection of Taenia solium DNA in the Urine of Neurocysticercosis Patients

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