Case Report: Use of Plasma Exchange Followed by Convalescent Plasma Therapy in a Critically Ill Patient with Severe Fever and Thrombocytopenia Syndrome-Associated Encephalopathy: Cytokine/Chemokine Concentrations, Viral Loads, and Antibody Responses

Choi Sungim; Kim Min-Chul; Kwon Ji-Soo; Kim Ji-Yeun; Lee Keun Hwa; Kim Sung-Han

首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Case Report: Use of Plasma Exchange Followed by Convalescent Plasma Therapy in a Critically Ill Patient with Severe Fever and Thrombocytopenia Syndrome-Associated Encephalopathy: Cytokine/Chemokine Concentrations, Viral Loads, and Antibody Responses

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Case Report: Use of Plasma Exchange Followed by Convalescent Plasma Therapy in a Critically Ill Patient with Severe Fever and Thrombocytopenia Syndrome-Associated Encephalopathy: Cytokine/Chemokine Concentrations, Viral Loads, and Antibody Responses

机译：案例报告：使用等离子体交换，然后进行临床血浆治疗，其严重发烧和血小板减少综合征相关的脑病：细胞因子/趋化因子浓度，病毒载体和抗体反应

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We describe the case of a patient with severe fever with thrombocytopenia syndrome (SFTS) complicated by SFTS-associated encephalopathy who was successfully treated with 4-day plasma exchange followed by two-time convalescent plasma therapy. During plasma exchange, the plasma cytokines interferon-a and inducible protein-10 gradually decreased without change of plasma viral load. However, plasma viral load gradually decreased after convalescent plasma therapy. This case provides important insights for understanding the mechanisms of experimental therapy in severely affected SFTS patients.

机译：我们描述了患有血小板减少症综合征（SFT）严重发烧的患者的患者，并通过SFTS相关的脑病复杂，他们成功地用4天的等离子体交换处理，然后进行了两次颠膜血浆治疗。在血浆交换期间，血浆细胞因子干扰素-A和诱导蛋白-10逐渐降低而不改变等离子体病毒载荷。然而，血浆病毒载体在临时血浆治疗后逐渐降低。本案例为了解严重影响的SFT患者的实验治疗机制提供了重要的见解。

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《The American Journal of Tropical Medicine and Hygiene》 |2018年第6期|共3页
作者
Choi Sungim; Kim Min-Chul; Kwon Ji-Soo; Kim Ji-Yeun; Lee Keun Hwa; Kim Sung-Han;
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作者单位

Univ Ulsan Coll Med Asan Med Ctr Dept Infect Dis 88 Olymp Ro 43 Gil Seoul 05505 South Korea;

Univ Ulsan Coll Med Asan Med Ctr Dept Infect Dis 88 Olymp Ro 43 Gil Seoul 05505 South Korea;

Univ Ulsan Coll Med Asan Med Ctr Dept Infect Dis 88 Olymp Ro 43 Gil Seoul 05505 South Korea;

Univ Ulsan Coll Med Asan Med Ctr Dept Infect Dis 88 Olymp Ro 43 Gil Seoul 05505 South Korea;

Jeju Natl Univ Coll Med Dept Microbiol &

Immunol Jeju South Korea;

Univ Ulsan Coll Med Asan Med Ctr Dept Infect Dis 88 Olymp Ro 43 Gil Seoul 05505 South Korea;

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正文语种 eng
中图分类地方病学;
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1. Case Report: Use of Plasma Exchange Followed by Convalescent Plasma Therapy in a Critically Ill Patient with Severe Fever and Thrombocytopenia Syndrome-Associated Encephalopathy: Cytokine/Chemokine Concentrations, Viral Loads, and Antibody Responses [J] . Choi Sungim, Kim Min-Chul, Kwon Ji-Soo, The American Journal of Tropical Medicine and Hygiene . 2018,第6期

机译：案例报告：使用等离子体交换，然后进行临床血浆治疗，其严重发烧和血小板减少综合征相关的脑病：细胞因子/趋化因子浓度，病毒载体和抗体反应
2. Plasma exchange to remove heparin-induced thrombocytopenia antibodies and the use of heparin during cardiopulmonary bypass in critically ill cardiac patients [J] . Bhavadharini Ramu, Rebecca J. Cogswell, Mark T. Reding, The Journal of heart and lung transplantation: the official publication of the International Society for Heart Transplantation . 2018,第8期

机译：血浆交换去除肝素诱导的血小板减少症抗体和肝素期间的肝素旁路在批评性心脏病患者中的使用
3. Anti-Ebola Virus Antibody Levels in Convalescent Plasma and Viral Load After Plasma Infusion in Patients With Ebola Virus Disease [J] . Brown Jerry F., Dye John M., Tozay Sam, The Journal of Infectious Diseases . 2018,第4期

机译：埃博拉病毒病患者血浆输注后逆埃博拉病毒抗体水平和病毒载量
4. Case Report: Use of Plasma Exchange Followed by Convalescent Plasma Therapy in a Critically Ill Patient with Severe Fever and Thrombocytopenia Syndrome–Associated Encephalopathy: Cytokine/Chemokine Concentrations Viral Loads and Antibody Responses [O] . Sungim Choi, Min-Chul Kim, Ji-Soo Kwon, 2018

机译：案例报告：使用血浆交换然后在严重发烧和血小板减少症综合征相关的脑病：细胞因子/趋化因子浓度病毒载荷和抗体反应中的临床血浆治疗
5. Concurrent measurement of dynamic changes in viral load, serum enzymes, T cell subsets, and cytokines in patients with severe fever with thrombocytopenia syndrome. [O] . Jun Li, Yaping Han, Yiping Xing, 2014

机译：同时测量严重发热伴血小板减少综合征患者的病毒载量，血清酶，T细胞亚群和细胞因子的动态变化。

Case Report: Use of Plasma Exchange Followed by Convalescent Plasma Therapy in a Critically Ill Patient with Severe Fever and Thrombocytopenia Syndrome-Associated Encephalopathy: Cytokine/Chemokine Concentrations, Viral Loads, and Antibody Responses

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