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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Risk Factors for Household Transmission of Vibrio cholerae in Dhaka, Bangladesh (CHoBI7 Trial)
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Risk Factors for Household Transmission of Vibrio cholerae in Dhaka, Bangladesh (CHoBI7 Trial)

机译：孟加拉国达卡（Chobi7审判）达卡霍乱家居传播风险因素

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Household contacts of cholera patients are at a 100 times higher risk of a Vibrio cholerae infection than the general population. To examine risk factors for V. cholerae infections and investigate intervention strategies among this population, we followed household contacts of cholera patients for the 1-week high-risk period after the index patient obtained care. This study was nested within a randomized controlled trial of the Cholera-Hospital-Based-Intervention-for-7-days (CHoBI7), a handwashing with soap and water treatment intervention in Dhaka, Bangladesh. Rectal swab results were available from 320 household contacts of cholera patients at five time points over a 1-week period. Fecal and water samples were analyzed for V. cholerae by bacterial culture. All analyses were stratified by study arm. Within the intervention arm, stored household drinking water with a median free chlorine concentration below 0.5 mg/L was associated with a three times higher odds of a cholera infection (odds ratio [OR]: 3.0; 95% confidence interval [CI]: 1.32, 6.63). In the control arm, having V. cholerae in stored water was associated with a significantly higher odds of a symptomatic cholera infection (OR: 8.66; 95% CI: 2.11, 35.48). No association was found between observed handwashing with soap at food and stool-related events and V. cholerae infections. Stored household drinking water with detectable V. cholerae and chlorine concentrations below the World Health Organization guideline were found to be important risk factors for cholera infection among household contacts of cholera patients. These findings emphasize the need for water treatment interventions targeting this high risk population.
机译：霍乱患者的家庭接触患者的风险高于一般人群的血管舒光感染的风险高100倍。为了检查霍乱感染和调查该人群的干预策略的风险因素，我们在指数患者获得护理后，我们遵循霍乱患者的霍乱患者的接触。本研究嵌套在霍乱医院的干预 - 7天（CHOBI7）的随机对照试验中，在孟加拉国达卡的洗手和水处理干预。直肠拭子结果可在霍乱患者的320名家用患者中获得，在1周内的五个时间点。通过细菌培养分析粪便和水样的V.霍乱。所有分析都是通过研究手臂分层的。在干预臂内，储存家用饮用水的中间氯浓度低于0.5mg / L.霍乱感染的少量少量的三倍（差距[或]：3.0; 95％置信区间[CI]：1.32 ，6.63）。在控制臂中，储存水中的V.霍乱霍乱与症状性霍乱感染的显着较高的几率有关（或：8.66; 95％CI：2.11,35.48）。在食物和粪便相关事件中观察到的用肥皂和霍乱感染之间没有发现任何关联。将储存家用饮用水与可检测的V.霍乱和氯浓度低于世界卫生组织指南，是霍乱患者家庭接触中霍乱感染的重要危险因素。这些调查结果强调了针对这种高风险群体的水处理干预的需求。

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    Burrowes Vanessa; Perin Jamie; Monira Shirajum; Sack David A.; Rashid Mahamud-ur; Mahamud Toslim; Rahman Zillur; Mustafiz Munshi; Bhuyian Sazzadul I.; Begum Farzana; Zohura Fatema; Biswas Shwapon; Parvin Tahmina; Hasan Tasdik; Zhang Xiaotong; Sack Bradley R.; Saif-Ur-Rahman K. M.; Alam Munirul; George Christine Marie;

  • 作者单位

    Johns Hopkins Bloomberg Sch Publ Hlth Dept Int Hlth Baltimore MD 21205 USA;

    Johns Hopkins Bloomberg Sch Publ Hlth Dept Int Hlth Baltimore MD 21205 USA;

    Bangladesh Icddr B Int Ctr Diarrheal Dis Res Dept Int Hlth Dhaka Bangladesh;

    Johns Hopkins Bloomberg Sch Publ Hlth Dept Int Hlth Baltimore MD 21205 USA;

    Bangladesh Icddr B Int Ctr Diarrhoeal Dis Res Ctr Communicable Dis Dhaka Bangladesh;

    Bangladesh Icddr B Int Ctr Diarrhoeal Dis Res Ctr Communicable Dis Dhaka Bangladesh;

    Bangladesh Icddr B Int Ctr Diarrhoeal Dis Res Ctr Communicable Dis Dhaka Bangladesh;

    Bangladesh Icddr B Int Ctr Diarrhoeal Dis Res Ctr Communicable Dis Dhaka Bangladesh;

    Bangladesh Icddr B Int Ctr Diarrhoeal Dis Res Ctr Communicable Dis Dhaka Bangladesh;

    Bangladesh Icddr B Int Ctr Diarrhoeal Dis Res Ctr Communicable Dis Dhaka Bangladesh;

    Bangladesh Icddr B Int Ctr Diarrhoeal Dis Res Ctr Communicable Dis Dhaka Bangladesh;

    Bangladesh Icddr B Int Ctr Diarrhoeal Dis Res Ctr Communicable Dis Dhaka Bangladesh;

    Bangladesh Icddr B Int Ctr Diarrhoeal Dis Res Ctr Communicable Dis Dhaka Bangladesh;

    Bangladesh Icddr B Int Ctr Diarrhoeal Dis Res Ctr Communicable Dis Dhaka Bangladesh;

    Johns Hopkins Bloomberg Sch Publ Hlth Dept Int Hlth Baltimore MD 21205 USA;

    Johns Hopkins Bloomberg Sch Publ Hlth Dept Int Hlth Baltimore MD 21205 USA;

    Bangladesh Icddr B Int Ctr Diarrhoeal Dis Res Ctr Communicable Dis Dhaka Bangladesh;

    Bangladesh Icddr B Int Ctr Diarrhoeal Dis Res Ctr Communicable Dis Dhaka Bangladesh;

    Johns Hopkins Bloomberg Sch Publ Hlth Dept Int Hlth Baltimore MD 21205 USA;

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  • 正文语种 eng
  • 中图分类 地方病学;
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