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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Case Report: Meningoencephalitis Caused by Reactivation of Chagas Disease in Patient without Known Immunosuppression
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Case Report: Meningoencephalitis Caused by Reactivation of Chagas Disease in Patient without Known Immunosuppression

机译:案例报告:未知免疫抑制患者患者的抗菌病引起的脑膜炎

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摘要

Central nervous system (CNS) involvement in Chagas disease (CD) is an uncommon complication that can result from direct involvement of the parasite or from thromboembolic phenomena. Direct involvement of CNS can occur in both acute and chronic forms of CD, and can also be secondary to reactivation. Reactivation of CD generally occurs in immunosuppjessed patients such as those with human immunodeficiency infection or malignancies being rarely described in patients without apparent immunosuppression. We report a case of a patient living for many years in a nonendemic area for CD that presented to the emergency department with sudden onset of neurological symptoms as a result of reactivation of the disease. The microorganism was isolated from cerebrospinal fluid, and despite appropriate use of benznidazole, the patient died of sepsis after 22 days of treatment. Further investigation did not show any apparent cause of immunosuppression. This case report shows the importance of considering the diagnostic possibility of neurological complications from CD reactivation in patients that have ever lived in CD-endemic areas even without apparent underlying immunosuppression.
机译:中枢神经系统(CNS)参与Chagas疾病(CD)是一种罕见的并发症,可能是由寄生虫的直接涉及或血栓栓塞现象引起的。 CNS的直接参与急性和慢性形式的CD可以发生,也可以是重新激活。 CD的再活化通常发生在免疫抑制患者中,例如具有人类免疫缺陷感染的患者或在没有明显免疫抑制的患者中很少描述的恶性肿瘤。我们举报了患者在患有疾病的疾病的非洲疾病地区的患者中居住多年的案例,以疾病重新激活突然发作神经症状。从脑脊液中分离微生物,尽管适当使用苯并咪唑,但患者在治疗22天后死于败血症。进一步调查没有显示出免疫抑制的任何明显原因。本案例报告表明,即使在没有明显的潜在免疫抑制中,考虑患者在患者中患者诊断为镉重新激活的诊断可能性的重要性。

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