Serological Evidence of Ebola Virus Infection in Rural Guinea before the 2014 West African Epidemic Outbreak

Keita Alpha K.; Butel Christelle; Thaurignac Guillaume; Diallo Aminata; Nioke Talla; Traore Falaye; Koivogui Lamine; Peeters Martine; Delaporte Eric; Ayouba Ahidjo

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Serological Evidence of Ebola Virus Infection in Rural Guinea before the 2014 West African Epidemic Outbreak

机译：2014年西非流行病爆发前几内亚埃博拉病毒感染的血清学证据

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Questions remain as to whether an unnoticed Ebola outbreak occurred in Guinea before the 2014-2016 epidemic. To address this, we used a highly sensitive and specific Luminex-based assay for Ebola virus (EBOV) antibody detection to screen blood samples collected in the framework of the Demographic Health Survey performed in 2012 in Guinea. One sample (GF069) of 1,483 tested was positive at very high immunoglobulin G titer to Zaire EBOV in Guinee Forestiere. Thus, at least 2 years before the 2014 EVD outbreak in Guinea, Zaire EBOV was circulating in rural areas of this country.

机译：问题仍然是在2014-2016流行病之前在几内亚发生了不受注意的埃博拉疫情。为了解决这一点，我们使用了对埃博拉病毒（EBOV）抗体检测的高敏感和特异性的Luminex测定，以对2012年在几内亚进行的人口健康调查框架中收集的血液样本。在Guinee Forestiere的Zaire Ebov的非常高的免疫球蛋白G滴度下测试的一个样品（GF069）为阳性。因此，在几内亚2014年EVD爆发前至少2年，Zaire Ebov在这个国家的农村传播。

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《The American Journal of Tropical Medicine and Hygiene》 |2018年第2期|共3页
作者
Keita Alpha K.; Butel Christelle; Thaurignac Guillaume; Diallo Aminata; Nioke Talla; Traore Falaye; Koivogui Lamine; Peeters Martine; Delaporte Eric; Ayouba Ahidjo;
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作者单位

Montpellier Univ IRD UMI 23 INSERM U1175 911 Ave Agropolis BP 64501 F-34394 Montpellier 5;

Montpellier Univ IRD UMI 23 INSERM U1175 911 Ave Agropolis BP 64501 F-34394 Montpellier 5;

Montpellier Univ IRD UMI 23 INSERM U1175 911 Ave Agropolis BP 64501 F-34394 Montpellier 5;

Inst Natl Sante Publ Conakry Guinea;

Inst Natl Sante Publ Conakry Guinea;

Inst Natl Sante Publ Conakry Guinea;

Inst Natl Sante Publ Conakry Guinea;

Montpellier Univ IRD UMI 23 INSERM U1175 911 Ave Agropolis BP 64501 F-34394 Montpellier 5;

Montpellier Univ IRD UMI 23 INSERM U1175 911 Ave Agropolis BP 64501 F-34394 Montpellier 5;

Montpellier Univ IRD UMI 23 INSERM U1175 911 Ave Agropolis BP 64501 F-34394 Montpellier 5;

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正文语种 eng
中图分类地方病学;
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1. Serological Evidence of Ebola Virus Infection in Rural Guinea before the 2014 West African Epidemic Outbreak [J] . Keita Alpha K., Butel Christelle, Thaurignac Guillaume, The American Journal of Tropical Medicine and Hygiene . 2018,第2期

机译：2014年西非流行病爆发前几内亚埃博拉病毒感染的血清学证据
2. Tackling emerging infections: clinical and public health lessons from the West African Ebola virus disease outbreak, 2014-2015 (vol 15, pg 457, 2015) [J] . Walker Naomi F., Whitty Christopher J. M. Clinical medicine: journal of the Royal College of Physicians of London . 2015,第6期

机译：解决新兴感染：2014-2015年西非埃博拉病毒病暴发的临床和公共卫生课程（第15卷，第457页，2015年）
3. Tackling emerging infections: clinical and public health lessons from the West African Ebola virus disease outbreak, 2014-2015 [J] . Walker Naomi F., Whitty Christopher J. M. Clinical medicine: journal of the Royal College of Physicians of London . 2015,第5期

机译：解决新兴感染：2014-2015年西非埃博拉病毒病暴发的临床和公共卫生课程
4. Understanding the Health Disaster: Research Design for the Response to the 2014 West African Ebola Outbreak [C] . Tina Comes, Bartel Van de Walle, Laura Laguna Humanitarian Technology Conference . 2015

机译：了解健康灾害：对2014年西非埃博拉疫情爆发的回应研究设计
5. Consequences of Short Term Mobility Across Heterogeneous Risk Environments: The 2014 West African Ebola Outbreak [D] . Espinoza, Baltazar Cortes. 2018

机译：跨异构风险环境的短期流动的后果：2014年西非埃博拉疫情爆发
6. Serological Evidence of Ebola Virus Infection in Rural Guinea before the 2014 West African Epidemic Outbreak [O] . Alpha K. Keita, Christelle Butel, Guillaume Thaurignac, 2018

机译：2014年西非流行病爆发前几内亚农村地区埃博拉病毒感染的血清学证据
7. Distinct lineages of Ebola virus in Guinea during the 2014 West African epidemic [O] . Etienne Simon-Loriere, Ousmane Faye, Oumar Faye, 2015

机译：2014年西非流行病在几内亚的埃博拉病毒的独特谱系

Serological Evidence of Ebola Virus Infection in Rural Guinea before the 2014 West African Epidemic Outbreak

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