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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Altered Systemic Adipokine Levels in Pulmonary Tuberculosis and Changes following Treatment
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Altered Systemic Adipokine Levels in Pulmonary Tuberculosis and Changes following Treatment

机译：改变了肺结核肺结核的全身互联网水平和治疗后的变化

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Pulmonary tuberculosis (PTB) is associated with modulation of levels of adipokines, specifically adiponectin and leptin, but the effect of standard antituberculosis treatment (ATT) on the systemic levels of adiponectin, resistin, and leptin has not been well explored. To identify the association of adipokines with PTB and their relationship with disease severity and bacterial burden, we measured the levels of adiponectin, resistin, and leptin in PTB individuals and compared them with latent tuberculosis (LTB) and healthy control (HC) individuals. Pulmonary tuberculosis was characterized by diminished circulating levels of adiponectin and leptin and heightened circulating levels of resistin in comparison to that in LTB and HC individuals. However, PTB with bilateral or cavitary disease did not exhibit any increased systemic levels of these adipokines in comparison with those with unilateral or non-cavitary disease, respectively. In addition, none of the adipokines exhibited a positive correlation with bacterial burdens, but adiponectin alone exhibited a negative correlation with body mass index in PTB individuals. Finally, on successful completion of ATT, PTB individuals exhibited significantly increased levels of adiponectin and leptin and significantly decreased levels of resistin. Therefore, our data identify an important association of systemic adipokine levels with PTB disease and its alteration following ATT.
机译：肺结核（PTB）与脂肪因子水平，特别是脂联素和瘦素的调节有关，但标准抗核分辨率治疗（ATT）对脂联素，抵抗汀和瘦素的系统水平的影响并未得到很好的探索。为了鉴定脂肪因子与PTB的关系及其与疾病严重程度和细菌负担的关系，我们测量了PTB个体中的脂联素，抵抗力和瘦素的水平，并将其与潜在结核病（LTB）和健康对照（HC）个体进行了比较。肺结核的特征在于，与LTB和HC个体相比，脂联素和瘦蛋白和瘦素的循环水平减少，并加强了抗性水平的循环水平。然而，与双侧或空腔疾病的PTB分别没有分别表现出这些脂肪因子的任何增加的全身水平，分别与单侧或非空间疾病的人相比。此外，没有一种adipokines与细菌负担表现出阳性相关性，但是脂联素单独表现出与PTB个体中的体重指数的负相关性。最后，在成功完成ATT的情况下，PTB个体表现出显着增加的脂联素和瘦素水平，并显着降低了抵抗力水平。因此，我们的数据鉴定了全身互联网水平与PTB疾病的重要协定及其在ATT之后的改变。

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