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首页> 外文期刊>The Australasian journal of dermatology >In situ and invasive melanoma in a high-risk, New Zealand, population: A population-based study
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In situ and invasive melanoma in a high-risk, New Zealand, population: A population-based study

机译：原位和侵入性黑素瘤在高风险，新西兰，人口：基于人口的研究

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Background Few population-based studies assess both invasive and in situ melanoma. We document all patients with a first biopsied melanoma in a general population in New Zealand (NZ). Methods All residents in a defined area of New Zealand with a biopsy showing a new primary invasive or in situ melanoma from 2010 to 2012 were identified, 974 patients; analysis used multivariate methods. Results Age-standardised incidence rates were 34.3 in females (F) and 41.4 in males (M) for invasive, 20.9 F and 27.6 M for in situ, and 55.2 F and 69.0 M for total melanoma. More in situ melanoma occurred in older patients and on the head and neck. Geometric mean Breslow thickness for invasive was 0.78 mm F and 0.85 mm M, with thicker lesions at ages over 60 and on the lower limb; there was no significant relationship with sex, distance from care or social deprivation assessed from residential address. Nodular melanomas (15%) were more frequent in older and male patients, and on the limbs, and were thicker. The estimated cumulative risk for melanoma is 4.4% F and 4.6% M by age 70. The body site distribution and sex differences were consistent with sun exposure patterns. Estimated incidence of melanoma in New Zealand in 2018 is 2500 invasive and 1700 in situ cases. Conclusions Assessing both in situ and invasive melanoma expands the clinical picture, better estimating health care demand and costs. Results suggest that in situ disease is a more slowly growing lesion than the early phase of invasive disease. The features of thicker or nodular melanoma show priorities for prevention and early detection.
机译：背景技术基于群体的研究评估了侵入性和原位黑色素瘤。我们将所有患者记录新西兰（NZ）的一般人群中的第一次活检黑素瘤。方法鉴定了从2010年至2012年到2012年的新西兰定义地区的所有居民，具有显示新的侵入性或原位黑素瘤的活组织检查，974名患者;分析使用多元方法。结果年龄标准化的发病率为34.3，女性（F）和41.4，用于原位的侵袭性，20.9f和27.6米，总黑素瘤55.2 f和69.0 m。更符合老年患者和头部和颈部发生的原位素瘤。用于侵入性的几何平均Breeslow厚度为0.78mm F和0.85 mm m，具有60多个和下肢的较厚病变;与住宅地址评估的护理或社会剥夺没有明显的关系。较老的患者和雄性患者和肢体中的结节黑素瘤（15％）更频繁，较厚。估计的黑素瘤的累积风险为4.4％F和4.6％米为70岁。身体部位分布和性差异与阳光照射模式一致。 2018年新西兰黑素瘤的估计发生率为2500名侵入性和1700个原位案件。结论评估原位和侵袭性黑素瘤扩大临床影像，更好地估算医疗保健需求和成本。结果表明，原位疾病的病变比侵入性疾病的早期阶段更慢。较厚或结节黑色素瘤的特征显示了预防和早期检测的优先级。

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