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首页> 外文期刊>The Australian and New Zealand journal of psychiatry >Altered resting-state dorsal anterior cingulate cortex functional connectivity in patients with post-traumatic stress disorder
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Altered resting-state dorsal anterior cingulate cortex functional connectivity in patients with post-traumatic stress disorder

机译：改变休息状态背侧递增的患者患者患者患者患者

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Objective: The brain functional alterations at regional and network levels in post-traumatic stress disorder patients are still unclear. This study explored brain functional alterations at regional and network levels in post-traumatic stress disorder patients with resting-state functional magnetic resonance imaging and evaluated the relationship between brain function and clinical indices in post-traumatic stress disorder. Methods: Amplitude of low-frequency fluctuation and seed-based functional connectivity analyses were conducted among typhoon survivors with (n = 27) and without post-traumatic stress disorder (n = 33) and healthy controls (n = 30) to assess the spontaneous brain activity and network-level brain function. Pearson correlation analyses were performed to examine the association of brain function with clinical symptom and social support. Results: Both the post-traumatic stress disorder group and the trauma-exposed control group showed decreased amplitude of low-frequency fluctuation in the dorsal anterior cingulate cortex relative to the healthy control group. The post-traumatic stress disorder group showed increased dorsal anterior cingulate cortex functional connectivity with the right paracentral lobule and bilateral precentral gyrus/postcentral gyrus relative to both control groups. Both traumatized groups exhibited decreased dorsal anterior cingulate cortex functional connectivity with the right hippocampus and left cerebellum relative to the healthy control group. More decreased dorsal anterior cingulate cortex functional connectivity with the right hippocampus was found in the post-traumatic stress disorder group. The Checklist-Civilian Version score positively correlated with functional connectivity between the dorsal anterior cingulate cortex and the right paracentral lobule as well as between the dorsal anterior cingulate cortex and the right precentral gyrus/postcentral gyrus. The social support was associated with functional connectivity between the dorsal anterior cingulate cortex and the bilateral precentral gyrus/postcentral gyrus as well as the dorsal anterior cingulate cortex and the left middle frontal gyrus. Conclusion: Trauma exposure may result in aberrant local and network-level functional connectivity in individuals with or without post-traumatic stress disorder. Altered amplitude of low-frequency fluctuation in the dorsal anterior cingulate cortex may be a predisposing risk factor for post-traumatic stress disorder development following trauma exposure. More prominent decreased dorsal anterior cingulate cortex functional connectivity with the right hippocampus might be specific in the post-traumatic stress disorder group. Improvement of social support might possibly be significant for post-traumatic stress disorder patients.
机译：目的：创伤后应激障碍患者区域和网络水平的脑功能改变仍不清楚。本研究探讨了休息状态功能磁共振成像后创伤后应激障碍后的区域和网络水平的脑功能改变，评估了创伤后应激障碍脑功能与临床指标之间的关系。方法：在具有（n = 27）的台风幸存者中进行低频波动和基于种子的功能连接分析的幅度，没有创伤后应力障碍（n = 33）和健康对照（n = 30）来评估自发性大脑活动和网络级脑功能。进行Pearson相关分析，以检查脑功能与临床症状和社会支持的关联。结果：后创伤后应激障碍组和创伤性对照组均显示出相对于健康对照组背侧铰接皮质中的低频波动幅度下降。创伤后应激障碍组显示含量增加的背侧铰接性与相对于两种对照组相对于两种对照组的右侧瓣腺和双侧前列腺血管/后中央回谱。所有受伤组都表现出与右海马和左脑细胞相对于健康对照组的背侧递减递增的函数连通性。在创伤后应力障碍组中发现了与右海马的背侧递减细胞功能连通性更多。检查表 - 民用版本与背侧铰接皮质和右侧腺鳞片之间的功能连接呈正相关，以及背侧铰接皮质和右前级旋转型/后腹腔/后中央转象。社会支持与背侧铰接皮质和双侧前术陀螺/后中央转象以及背侧铰接皮质和左中间转位之间的功能连通性有关。结论：创伤暴露可能导致有或没有创伤后应力障碍的个体中的异常局部和网络级功能连接。背侧铰接皮层中的低频波动的改变幅度可能是创伤后创伤后应激障碍发育的概述风险因素。更突出的背侧铰接皮质与右海马的函数连接可能是特异性的，在后创伤后应激障碍组。改善社会支持可能对创伤后应激障碍患者可能具有重要意义。

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