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首页> 外文期刊>The Australian and New Zealand journal of psychiatry >Ketamine as a new treatment for depression: A review of its efficacy and adverse effects.
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Ketamine as a new treatment for depression: A review of its efficacy and adverse effects.

机译：氯胺酮作为抑郁症的新治疗方法：审查其疗效和不良影响。

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摘要

Objective: Narrative review of the literature on the efficacy and safety of subanaesthetic doses of ketamine for the treatment of depression. Method: Medline and PubMed databases were searched up to October 2012 using appropriate keywords. Results: The studies consistently report substantial efficacy with high response and remission rates from 4 to 72 hours (averages 77% and 43%, respectively) from single doses, though not all patients respond to ketamine. Early relapse is common. While the usual procedure involves the administration of intravenous ketamine at a dose of 0.5 mg/kg over 40 minutes, some preliminary evidence suggests other dosing regimens and routes of administration may be useful or even better. Repeated doses and maintenance pharmacological treatments have been investigated in order to prolong the antidepressant effects, with only modest success. Conclusions: Current research on the antidepressant effects of ketamine has consistently shown rapid and substantial improvement in mood in the majority of patients. However, these effects have often been found to be short-lived. Future research should focus on identifying predictors of response (e.g. clinical, genetic, pharmacokinetic, environmental), examining different dosing regimens and routes of administration, and strategies to maintain the antidepressant response.
机译：目的：对氯胺酮病毒剂量治疗抑郁症疗效和安全性的文献叙事述评。方法：使用适当的关键字在2012年10月到10月搜索Medline和PubMed数据库。结果：研究始终如一地向单剂量的4至72小时（分别为77％和43％，分别为77％和43％）的大量疗效，尽管并非所有患者都反应氯胺酮。早期复发很常见。虽然通常的程序涉及在40分钟内为0.5mg / kg的剂量施用静脉内氯胺酮，但一些初步证据表明其他给药方案和给药途径可能是有用的或更好的。已经研究了重复剂量和维持药理治疗以延长抗抑郁作用，只有适度的成功。结论：目前对氯胺酮抗抑郁作用的研究一直显示大多数患者情绪的快速和大幅提高。然而，这些效果通常被发现是短暂的。未来的研究应该侧重于识别反应预测因子（例如临床，遗传，药代动力学，环境），检查不同给药方案和给药途径，以及维持抗抑郁症应答的策略。

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