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首页> 外文期刊>The Australian and New Zealand journal of psychiatry >Association between nonmedical use of opioids or sedatives and suicidal behavior among Chinese adolescents: An analysis of sex differences
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Association between nonmedical use of opioids or sedatives and suicidal behavior among Chinese adolescents: An analysis of sex differences

机译：非医疗用途的阿片类药物或镇静剂与中国青少年的自杀行为之间的关系：性别差异分析

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Objective: The rising rate of suicidal behavior among adolescents is a growing concern, and sex differences may induce differential exposure to prescription drug misuse or suicidal behavior. We estimated, among Chinese adolescents, (1) the prevalence of nonmedical use of prescription drugs, suicidal ideation and suicide attempts; (2) whether nonmedical use of prescription drugs was independently associated with suicidal ideation and suicide attempts; and (3) whether there were sex differences in the associations. Methods: This was a secondary analysis of the data drawn from the 2015 National School-based Chinese Adolescents Health Survey. A total of 94,911 students completed questionnaires and qualified for our survey (response rate: 93.7%). All analyses were conducted separately for boys and girls. Results: There were significant sex differences in the prevalence of opioid or sedative misuse, and the sources and reasons for nonmedical use of prescription drugs (p < 0.05). The prevalence of suicidal ideation or suicide attempts was significantly higher in girls than in boys (suicidal ideation: 17.9% among girls vs 14.1% among boys; suicide attempts: 3.5% among girls vs 2.7% among boys). Among girls, frequent use of opioids was associated with an increased risk of suicidal ideation (adjusted odds ratio = 1.84, 95% confidence interval = [1.57, 2.17]) and suicide attempts (adjusted odds ratio = 2.96, 95% confidence interval = [2.34, 3.74]), and frequent use of sedatives was also positively associated with suicidal ideation (adjusted odds ratio = 2.23, 95% confidence interval = [1.91, 2.60]) and suicide attempts (adjusted odds ratio = 4.02, 95% confidence interval = [3.25, 4.99]). These associations were also statistically significant in boys, but the magnitudes of adjusted odds ratios for the associations between frequent use of opioids and sedatives and suicidal behavior were greater in girls than boys. Conclusion: There exist significant sex differences in the prevalence rates of nonmedical use of prescription drugs and suicidal behavior, and the child's sex plays a role in the association between nonmedical use of prescription drugs and suicidal behavior. The significant sex differences found above may provide a basis for early identification of adolescents at high risk of suicidal behavior.
机译：目的：青少年的自杀行为率上升是一种日益增长的问题，性别差异可能会诱导差别暴露于处方药滥用或自杀行为。我们估计，在中国青少年中，（1）非医疗用途的患病率，自杀性思想和自杀企图; （2）非医疗药物是否与自杀式念头和自杀企图独立相关; （3）协会是否存在性别差异。方法：这是从2015年全国校有的中国青少年卫生调查中汲取的数据的二级分析。共有94,911名学生完成调查问卷并合格进行调查（响应率：93.7％）。所有分析都分开为男孩和女孩进行。结果：阿片类药物或镇静滥用的患病率存在​​显着性差异，以及处方药的非医疗用途的来源和原因（P <0.05）。女孩的患病率或自杀企图的患病率在女孩身上显着高于男孩（自杀意念：17.9％的女孩，男孩之间的14.1％;自杀企图：男孩之间的3.5％vs 2.7％）。在女孩中，频繁使用阿片类药物的发生态度的风险增加（调节的差距= 1.84,95％置信区间= [1.57,2.17]）和自杀式速度（调整的赔率比= 2.96,95％置信区间= [ 2.34,3.74]），频繁使用镇静剂与自杀素段呈正相关（调节的差距= 2.23,95％置信区间= [1.91,2.60]）和自杀次数（调整后的差距= 4.02，95％置信区间= [3.25,4.99]）。这些关联在男孩中也有统计学意义，但在女孩频繁使用的关联的调节差距和沉积物之间的次数大于男孩比男孩更大。结论：处方药和自杀行为的非医疗利用患病率存在​​显着性差异，儿童的性别在非医疗使用处方药和自杀行为之间的关联中发挥作用。以上发现的显着性差异可以为早期识别青少年的高危行为的依据提供基础。

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