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首页> 外文期刊>The Australian and New Zealand journal of psychiatry >Does specific psychopathology predict development of psychosis in ultra high-risk (UHR) patients?
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Does specific psychopathology predict development of psychosis in ultra high-risk (UHR) patients?

机译：特异性精神病理学是否预测超高风险（UHR）患者的精神病发展？

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Studies have attempted to identify additional risk factors within the group identified as 'ultra high risk' (UHR) for developing psychotic disorders in order to characterise those at highest risk. However, these studies have often neglected clinical symptom types as additional risk factors. We aimed to investigate the relationship between baseline clinical psychotic or psychotic-like symptoms and the subsequent transition to a psychotic disorder in a UHR sample.A retrospective 'case-control' methodology was used. We identified all individuals from a UHR clinic who had subsequently developed a psychotic disorder (cases) and compared these to a random sample of individuals from the clinic who did not become psychotic within the sampling time frame (controls). The sample consisted of 120 patients (60 cases, 60 controls). An audit tool was used to identify clinical symptoms reported at entry to the clinic (baseline) using the clinical file. Diagnosis at transition was assessed using the Operational Criteria for Psychotic Illness (OPCRIT) computer program. The relationship between transition to a psychotic disorder and baseline symptoms was explored using survival analysis.Presence of thought disorder, any delusions and elevated mood significantly predicted transition to a psychotic disorder. When other symptoms were adjusted for, only the presence of elevated mood significantly predicted subsequent transition (hazard ratio 2.69, p = 0.002). Thought disorder was a predictor of transition to a schizophrenia-like psychotic disorder (hazard ratio 3.69, p = 0.008).Few individual clinical symptoms appear to be predictive of transition to a psychotic disorder in the UHR group. Clinicians should be cautious about the use of clinical profile alone in such individuals when determining who is at highest risk.
机译：研究已经试图确定鉴定为“超高风险”（UHR）的额外危险因素，用于开发精神病疾病，以表征最高风险。然而，这些研究通常被忽视临床症状类型作为额外的危险因素。我们的旨在调查基线临床精神病或精神病症状之间的关系，随后过渡到UHR样品中的精神病障碍。使用回顾性“案例控制”方法。我们鉴定了来自UHR诊所的所有个人随后开发了精神病障碍（病例），并将这些与未成为采样时间范围（控制）内没有成为精神病的诊所的随机样本。该样品由120名患者组成（60例，60例，对照）。使用临床档案，使用审核工具识别在进入诊所（基线）时报告的临床症状。使用手术性疾病（OPCRIT）计算机程序的操作标准评估转换的诊断。使用存活分析探讨了对精神病障碍和基线症状的过渡与基线症状的关系。思想障碍的阶段，任何妄想和升高的情绪明显预测到精神病障碍的过渡。当调整其他症状时，只有升高的情绪的存在显着预测后续过渡（危险比2.69，P = 0.002）。思想紊乱是转型到精神分裂症样精神病症的预测因子（危险比3.69，p = 0.008）.Few个体临床症状似乎是对UHR组中的精神病障碍的过渡预测。当确定谁处于最高风险时，临床医生应对单独使用临床剖面持谨慎态度。

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