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首页> 外文期刊>The Australian and New Zealand journal of psychiatry >White matter integrity alterations in young healthy adults reporting childhood trauma: A diffusion tensor imaging study
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White matter integrity alterations in young healthy adults reporting childhood trauma: A diffusion tensor imaging study

机译：年轻健康成年人的白质诚信改变报告儿童创伤：一种扩散张量成像研究

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摘要

Objective: To date, insufficient studies have focused on the relationship between childhood trauma and white matter integrity changes in healthy subjects. The aim of the present study was to explore the potential effects of childhood trauma on white matter microstructural changes by using voxel-based diffusion tensor imaging (DTI) to examine alterations in fractional anisotropy (FA) values in a group of young healthy adults. Methods: A total of 21 healthy adults with a history of childhood trauma exposures and 21 age- and sex-matched individuals without childhood trauma were recruited in the present study. The Childhood Trauma Questionnaire was used to assess five aspects of childhood trauma exposures. DTI data were obtained on a Philips 3.0-Tesla scanner. Voxelbased analysis was conducted to compare white matter FA values between groups. Results: Adults with self-reported childhood trauma experiences showed decreased white matter FA values in the genu and body of the corpus callosum and the left occipital fusiform gyrus (p < 0.001 uncorrected, voxel > 100). There was no significant difference in FA values between individuals with single and multiple childhood trauma exposures at the defined threshold. Conclusion: Our findings suggest that childhood trauma is associated with reduced microstructural integrity of the white matter in adulthood. These effects are still evident even in the absence of current psychiatric or medical symptoms, which may represent the vulnerability for developing mental disorders after childhood trauma experiences.
机译：目的：迄今为止，研究不足的研究专注于健康受试者儿童创伤与白质完整性变化之间的关系。本研究的目的是通过使用基于体素的扩散张量成像（DTI）来探讨儿童创伤对白质微观结构变化的潜在影响，以检查一组年轻健康成年人中分数各向异性（FA）值的变化。方法：在本研究中招募了共有21名具有儿童创伤疫苗历史和21例年龄和性匹配个体的健康成年人。童年创伤问卷用于评估儿童创伤暴露的五个方面。在飞利浦3.0-Tesla扫描仪上获得了DTI数据。进行Voxelbased分析以比较组之间的白质FA值。结果：具有自我报告的儿童创伤体验的成年人在语料库胼um和左侧枕骨梭形子宫中的白质成本下降表现下降（P <0.001未矫正，voxel> 100）。在定义的阈值下单个和多个儿童创伤曝光的个体之间的FA值没有显着差异。结论：我们的研究结果表明，儿童创伤与成年白质的微观结构完整性降低。即使在没有目前的精神病或医学症状的情况下，这些效果仍然是显而易见的，这可能代表儿童创伤经历后发育精神障碍的脆弱性。

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    LuS.; WeiZ.; GaoW.; WuW.; LiaoM.; ZhangY.; LiW.; LiZ.; LiL.;

  • 作者单位

    Key Laboratory of Psychiatry and Mental Health of Hunan Province Central South University Second;

    Key Laboratory of Psychiatry and Mental Health of Hunan Province Central South University Second;

    Key Laboratory of Psychiatry and Mental Health of Hunan Province Central South University Second;

    Key Laboratory of Psychiatry and Mental Health of Hunan Province Central South University Second;

    Key Laboratory of Psychiatry and Mental Health of Hunan Province Central South University Second;

    Key Laboratory of Psychiatry and Mental Health of Hunan Province Central South University Second;

    Key Laboratory of Psychiatry and Mental Health of Hunan Province Central South University Second;

    Key Laboratory of Psychiatry and Mental Health of Hunan Province Central South University Second;

    Key Laboratory of Psychiatry and Mental Health of Hunan Province Central South University Second;

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  • 正文语种 eng
  • 中图分类 神经病学与精神病学;
  • 关键词

    Childhood trauma; diffusion tensor imaging (DTI); fractional anisotropy (FA);

    机译：儿童创伤;扩散张量成像（DTI）;分数各向异性（FA）;

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