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首页> 外文期刊>The Australian and New Zealand journal of psychiatry >Effect of stress gene-by-environment interactions on hippocampal volumes and cortisol secretion in adolescent girls
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Effect of stress gene-by-environment interactions on hippocampal volumes and cortisol secretion in adolescent girls

机译：应激基因 - 环境相互作用对青少年女孩海马体积和皮质醇分泌的影响

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Objective: Adolescence is a time of increased susceptibility to environmental stress and mood disorders, and girls are particularly at risk. Genes interacting with the environment (G x E) are implicated in hypothalamic-pituitary-adrenal axis dysregulation, hippocampal volume changes and risk or resilience to mood disorders. In this study, we assessed the effects of stress system G x E interactions on hippocampal volumes and cortisol secretion in adolescent girls. Methods: We recruited 229 girls aged 12-18 years, and scans were obtained from 202 girls. Of these, 76 had been exposed to higher emotional trauma (abuse or neglect). Hippocampal volumes were measured using Freesurfer and high-resolution structural magnetic resonance imaging scans. Saliva samples were collected for measurement of cortisol levels and genotyping of stress system genes: FKBP5, NR3C1 (both N = 194) and NR3C2 (N = 193). Results: Among girls with the 'G' allelic variant of the NR3C1 gene, those who had been exposed to higher emotional trauma had significantly smaller left hippocampal volumes (N = 44; mean = 4069.58 mm(3), standard deviation = 376.99) than girls who had been exposed to minimal emotional trauma with the same allelic variant (N = 69; mean = 4222.34 mm(3), standard deviation = 366.74). Conclusion: In healthy adolescents, interactions between emotional trauma and the 'protective' NR3C1 'GG' variant seem to induce reductions in left hippocampal volumes. These G x E interactions suggest that vulnerability to mood disorders is perhaps driven by reduced 'protection' that may be specific to emotional trauma. This novel but preliminary evidence has implications for targeted prevention of mood disorders and prospective multimodal neuroimaging and longitudinal studies are now needed to investigate this possibility.
机译：目的：青春期是对环境压力和情绪障碍的易感性增加的时间，女孩特别有风险。与环境相互作用的基因（G X E）涉及下丘脑 - 垂体 - 肾上腺轴的缺陷，海马体积变化和风险或适应情绪障碍。在这项研究中，我们评估了应力系统G X E相互作用对海马体积和皮质醇分泌在青少年女孩中的影响。方法：我们招聘了12-18岁的229名女孩，并从202名女孩获得了扫描。其中，76人已经暴露于更高的情绪创伤（滥用或忽视）。使用FreeSurfer和高分辨率结构磁共振成像扫描测量海马体积。收集唾液样品以测量胁迫系统基因的皮质醇水平和基因分型：FKBP5，NR3C1（N = 194）和NR3C2（n = 193）。结果：在NR3C1基因的“G”等位基因变体中的女孩中，那些暴露于更高的情绪创伤的人左海马体积显着较小（n = 44;平均值= 4069.58 mm（3），标准偏差= 376.99）暴露于具有相同等位基因变体的最小情绪创伤的女孩（n = 69;平均值= 4222.34 mm（3），标准偏差= 366.74）。结论：在健康青少年，情绪创伤与“保护”NR3C1'GG'变体之间的相互作用似乎诱导左海马体积的减少。这些g x e互动表明，对情绪障碍的脆弱性可能是通过减少的“保护”来驱动，这可能是情绪创伤的。这部小说但初步证据对目标疾病的有针对性的预防而言，现在需要预防潜在的多模式神经影像学和纵向研究来研究这种可能性。

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