Fingolimod exacerbated affective psychosis?

Alyssa Fitzpatrick; Scott R Clark; Rowena Newcombe; Anthony Davis; Bernhard T Baune

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Fingolimod exacerbated affective psychosis?

机译：Fingolimod加剧了情感精神病症吗？

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Fingolimod (FTY720) is a sphingosine-I -phosphate (SIP) receptor modulator indicated in the treatment of relapsing-remitting multiple sclerosis (MS). Acting as a receptor antagonist, it inhibits the release of potentially auto-reactive T and B cells from the thymus, preventing entry into the central nervous system (CNS). Clinical trials have shown equivalent rates of depression in treatment and control groups (Scott, 2011). No report has been made of mania or psychosis associated with fingolimod treatment.

机译：Fingolimod（Fty720）是一种鞘氨醇-i-磷酸（SIP）受体调节剂，用于治疗复发延迟多发性硬化（MS）。作为受体拮抗剂，它抑制来自胸腺的潜在自动反应性T和B细胞的释放，防止进入中枢神经系统（CNS）。临床试验显示了治疗和对照组的等同抑郁率（斯科特，2011）。没有报告的躁狂症或与Fingolimod治疗有关的精神病。

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《The Australian and New Zealand journal of psychiatry》 |2013年第4期|共2页
作者
Alyssa Fitzpatrick; Scott R Clark; Rowena Newcombe; Anthony Davis; Bernhard T Baune;
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正文语种 eng
中图分类神经病学与精神病学;
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1. Fingolimod exacerbated affective psychosis? [J] . Alyssa Fitzpatrick, Scott R Clark, Rowena Newcombe, The Australian and New Zealand journal of psychiatry . 2013,第4期

机译：Fingolimod加剧了情感精神病症吗？
2. Severe Exacerbation of Psychosis After Sudden Withdrawal of Chlorpromazine in the Treatment of Methamphetamine-Associated Psychosis With Aripiprazole and Chlorpromazine: 2 Case Reports [J] . Wang Gang, Thakoor Jaya Prishni Devi, Wang Xuyi, Journal of addiction medicine . 2014,第6期

机译：突然停用氯丙嗪治疗甲基苯丙胺相关性精神病的阿立哌唑和氯丙嗪治疗后，精神病严重加重：2例报告
3. Severe Exacerbation of Multiple Sclerosis Following Withdrawal of Fingolimod [J] . Fragoso Yara D., Adoni Tarso, Gomes Sidney, Clinical drug investigation . 2019,第9期

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5. Neuroprotective Properties of Fingolimod in an Experimental Model of Multiple Sclerosis-Induced Optic Neuritis [D] . Candadai, Amritha Anand. 2020

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7. Polygenic risk score for schizophrenia was not associated with glycemic level (HbA1c) in patients with non-affective psychosis: Genetic Risk and Outcome of Psychosis (GROUP) cohort study [O] . Tesfa Dejenie Habtewold, Md. Atiqul Islam, Edith J. Liemburg, 2020

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Fingolimod exacerbated affective psychosis?

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