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首页> 外文期刊>The Australian and New Zealand journal of psychiatry >Antidepressants: The scapegoat of poor outcome bipolar disorder?
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Antidepressants: The scapegoat of poor outcome bipolar disorder?

机译：抗抑郁药：差异差异双相情感障碍的替罪羊？

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摘要

Like so many constructs within psychiatry, antidepressants in the treatment of bipolar disorder have become the object of a split that renders them as being either 'all good' or 'all bad' in the eyes of many practitioners. Early case reports in the 1960s and 1970s noted that some depressed patients may develop manic or hypomanic symptoms soon after beginning a tricy-clic antidepressant (TCA) or mono-amine oxidase inhibitor (MAOI). Those observations in turn led investigators in the 1980s to pose the intriguing hypothesis that antidepressants might acutely nudge some depressed patients from depression into mania or hypomania, overshooting euthymia; longer term, they may increase the frequency of subsequent episodes of either polarity. Despite minimal systematic, prospective research to evaluate this hypothesis, the field seemingly overnight embraced this proposition as dogma.
机译：类似于精神病学中的许多构建体，治疗双相情感障碍的抗抑郁药已经成为一个分裂的对象，使他们在许多从业者的眼中成为“全部好”或“全部糟糕”。 20世纪60年代和20世纪70年代的早期案例报告指出，一些抑郁的患者在开始三氯藻抗抑郁药（TCA）或单胺氧化酶抑制剂（MAOI）之后，一些抑郁的患者可能不得发育躁狂症或恶性症状。 这些观察结果在20世纪80年代，引领了LED调查人员提出了抗抑郁药可能急剧地向令人抑制的患者急剧下降到躁狂症或丘比西亚的抑郁症或羞怯的患者; 长期来看，它们可能会增加后续剧集的两极性的频率。 尽管系统性，前瞻性研究最小，但评估了这一假设，但该领域似乎过夜将此命题作为教条作为教条。

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