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首页> 外文期刊>The Australian and New Zealand journal of psychiatry >Is there a role for antibodies targeting muscarinic acetylcholine receptors in the pathogenesis of schizophrenia?
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Is there a role for antibodies targeting muscarinic acetylcholine receptors in the pathogenesis of schizophrenia?

机译：是否存在针对精神分裂症发病机制的抗体靶向毒蕈碱乙酰胆碱受体的作用？

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Objective: Muscarinic receptor dysfunction has been suggested to play an important role in the pathophysiology of schizophrenia. Recently, it has also become clear that immune reactivity directed against neurotransmitter receptors may play a pathogenic role in some cases of schizophrenia. The aim of this review is to summarize the case for muscarinic receptor dysfunction in schizophrenia and the evidence supporting the hypothesis that this dysfunction is related to the development of muscarinic receptor-targeting antibodies. Method: The article reviews studies of muscarinic receptors and the presence and potential role(s) of anti-muscarinic acetylcholine receptor antibodies in people with schizophrenia. Results: There is accumulating evidence that altered or deficient muscarinic signalling underlies some of the key clinical features of schizophrenia. Although the number of studies investigating anti-muscarinic acetylcholine receptor antibodies in schizophrenia is relatively small, they consistently demonstrate that such antibodies are present in a proportion of patients. This evidence suggests that these antibodies could have pathogenic effects or exist as a biomarker to an unknown pathophysiological process in schizophrenia. Conclusion: The presence of elevated levels of anti-muscarinic acetylcholine receptor antibodies may identify a subgroup of people with schizophrenia, potentially informing aetiopathogenesis, clinical presentation and treatment. To date, all studies have examined antibodies in participants with chronic schizophrenia, who have likely received antipsychotic medication for many years. As these medications modulate immune functions and regulate receptor densities, it is recommended that future studies screen for the presence of anti-muscarinic antibodies in people experiencing their first episode of psychosis.
机译：目的：已经提出毒蕈碱受体功能障碍在精神分裂症的病理生理学中发挥着重要作用。最近，它还显然，针对神经递质受体的免疫反应性可能在某些精神分裂症病例中发挥病原作用。本综述的目的是总结精神分裂症中的肌肉蛋白受体功能障碍以及支持该功能障碍与毒蕈碱受体靶向抗体的发育有关的证据的证据。方法：文章综述了肌肉蛋白受体的研究以及精神分裂症人们抗毒蕈碱乙酰胆碱受体抗体的存在和潜在作用。结果：累积的证据累积，毒蕈碱信号传导的改变或缺乏缺乏精神分裂症的关键临床特征。尽管研究精神分裂症中的抗毒蕈碱乙酰胆碱受体抗体的研究数量相对较小，但它们一致地证明这种抗体以比例存在的患者存在。该证据表明，这些抗体可以具有致病作用或作为生物生理生理过程中的生物标志物存在于精神分裂症中。结论：抗毒蕈碱乙酰胆碱受体抗体升高的存在可以鉴定有精神分裂症的人群，可能会通知Aetiop病变，临床介绍和治疗。迄今为止，所有研究均检查了慢性精神分裂症的参与者的抗体，他们可能多年接受抗精神病药物。由于这些药物调节免疫功能并调节受体密度，建议未来的研究筛查在经历其第一次精神病发作的人们中存在抗毒蕈碱抗体。

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