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首页> 外文期刊>The anatomical record: advances in integrative anatomy and evolutionary biology >Experimental Studies on Facial Nerve Regeneration
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Experimental Studies on Facial Nerve Regeneration

机译：面神经再生的实验研究

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ABSTRACT Insufficient recovery after injury of a peripheral motor nerve is due to (1) inappropriate pathfinding as a result of axonal regrowth to inappropriate targets, (2) excessive collateral axonal branching at the lesion site, and (3) polyinnervation of the neuromuscular junctions (NMJs). The rat facial nerve model is often used because of its simple and reliable readout to measure recovery of function (vibrissal whisking). Over the last decades scientists have concentrated their efforts to combat mostly NMJ polyinnervation, because it turned out to be very difficult to reduce collateral axonal branching and impossible to navigate thousands of axons toward the original fascicles. In the past, several groups of scientists concentrated their efforts to reduce the activity‐dependent polyinnervation of NMJs by electrical stimulation of the muscles (square 0.1 msec pulses at 5 Hz). The results showed no recovery of functions and a severe reduction in the number of innervated NMJs to approximately one fifth of those observed in intact animals. More recent experiments, however, have shown that motor recovery improved significantly following mechanical stimulation of the denervated facial muscles (vibrissal and orbicularis oculi) and that restored functions could invariably be linked to reduced polyinnervation at the NMJ while the number of innervated NMJ remained the same. These results suggest that clinically feasible and effective therapies could be developed and tested in the near future. Anat Rec, 302:1287–1303, 2019. ? 2019 Wiley Periodicals, Inc.
机译：摘要外周动力损伤后的恢复不足是由于（1）由于轴突再生而不是恰当的靶标，（2）病变位点过多的侧支轴突分枝，（3）神经肌肉连接点的聚丙酯（3） nmjs）。通常使用大鼠面神经模型，因为其简单可靠的读数来测量功能的恢复（vibriarsal搅拌）。在过去的几十年中，科学家专注于努力打击大多数NMJ Polyinvervation，因为它结果很难减少抵押轴突分支，并且不可能向原始束缚迈出数千个轴突。过去，几个科学家群体集中了他们努力通过电刺激肌肉（5Hz处为0.1毫秒脉冲的电刺激来减少NMJ的活动依赖性多元化。结果表明，没有恢复功能和严重降低的原因，在完整动物中观察到的大约五分之一。然而，最近的实验表明，在机械刺激后肌肉（vibrissal和orbicularis oculi）的机械刺激之后，电动机恢复显着改善，并且恢复的功能可以总是与NMJ的减少的Polyinnervation相关联，而接驳的NMJ的数量保持不变。这些结果表明，可以在不久的将来开发和测试临床上可行和有效的疗法。 ANAT REC，302：1287-1303,2019 2019 Wiley期刊，Inc。

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