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首页> 外文期刊>The breast journal >Impact of 2013 ASCO ASCO / CAP HER CAP HER 2 reporting guidelines in breast cancer: An assessment study from Indian oncology centre that primarily performs HER HER 2 IHC IHC testing with special emphasis on IHC IHC equivocal category
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Impact of 2013 ASCO ASCO / CAP HER CAP HER 2 reporting guidelines in breast cancer: An assessment study from Indian oncology centre that primarily performs HER HER 2 IHC IHC testing with special emphasis on IHC IHC equivocal category

机译：2013年ASCO ASCO / CAP她的第2次乳腺癌报告指南的影响：来自印度肿瘤学中心的评估研究，主要是在IHC IHC等强调IHC IHC的特殊重点上表演她的2 IHC IHC测试

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摘要

Abstract The ASCO / CAP guidelines for HER 2 reporting in breast cancer published in 2007 and were updated in 2013 to assure that the right patient receives the targeted therapy. The updated guidelines have lowered the threshold for HER 2 positivity criteria and altered the equivocal category for both IHC and FISH . This first study from India addresses the impact of these updated guidelines in the various reporting categories at a tertiary care centre. We compared the trend of HER 2 IHC reporting 1?year before (Period A) and 1?year after (Period B) the implementation of updated 2013 ASCO / CAP guidelines. All HER 2 equivocal IHC cases of post 2013 guidelines were reclassified as per 2007 guidelines to detect additional number of cases that have been put into equivocal category. Reflex FISH correlation was also assessed to detect any additional cases eligible for anti HER 2 therapy with implementation of these updated guidelines. With implementation of updated 2013 guidelines, there was significant decrease in the number of cases scored as 1+ (from 30.7% to 20.6%; P value: .0001) while significant increase in number of 2+ cases (from 20.2% to 27.3%; P value: .004). Post 2013 guidelines, 39% (64 cases) of tumors were additionally put into the equivocal category which would have been considered as negative (score 1+) as per 2007 guidelines. The reflex FISH testing in these equivocal cases resulted in detection of only 1.5% of additional cases eligible for anti HER 2 therapy. With implementation of updated 2013 guidelines, there is no significant increase in HER 2 positivity trend. However, there is appreciable increase in IHC equivocal cases which subsequently led to increased reflex FISH testing without significantly contributing to the detection of additional eligible cases for anti HER 2 therapy, but resulted in delaying of definite HER 2 status along with financial implications.
机译：摘要2007年发布的乳腺癌2次报告的ASCO / CAP指南，并于2013年更新，以确保合适的患者收到有针对性的疗法。更新的指导方针降低了她的2个积极性标准的阈值，并改变了IHC和鱼类的等常数类别。从印度的第一次研究解决了这些更新的指导方针在三级护理中心的各种报告类别中的影响。我们比较了她2个IHC报告的趋势1？之前（a）和1？之后（b）在执行最新2013年ASCO / CAP指南的年度之后。邮政2013年邮政的所有2个等离子体IHC案件根据2007年重新分类，以检测已被规范类别的额外案件。还评估了反射鱼类相关性，以检测有资格获得抗她的2种治疗的任何额外案件，并在实施这些更新的准则。通过实施更新的2013年指南，分为1+的案件数量显着下降（从30.7％到20.6％; P值：.0001），而2个案例的数量显着增加（从20.2％到27.3％ ; p值：.004）。邮政2013年指南，39％（64例）肿瘤另外投入到等因素类别中，这些类别将被视为每2007年指南的负数（得分1+）。这些等圆形病例中的反射鱼类测试导致检测只有1.5％的额外案例符合抗她的2疗法。通过实施更新的2013年指南，她的2个积极性趋势没有显着增加。然而，IHC等圆锥病例的明显增加，随后导致反射鱼类测试增加，而不会显着促进检测额外的抗身案例的抗她的2疗法，但导致延迟她的2个地位以及财务影响。

著录项

  • 来源
    《The breast journal》 |2018年第4期|共5页
  • 作者

    Pasricha Sunil; Gupta Gurudutt; Garg Ritu; Sharma Anila; Gandhi Jatin S.; Durga Garima; Kamboj Meenakshi; Grover Shrruti; Mehta Anurag;

  • 作者单位

    Department of Histopathology and CytopathologyRajiv Gandhi Cancer Institute &

    Research CentreDelhi;

    Department of Histopathology and CytopathologyRajiv Gandhi Cancer Institute &

    Research CentreDelhi;

    Department of Histopathology and CytopathologyRajiv Gandhi Cancer Institute &

    Research CentreDelhi;

    Department of Histopathology and CytopathologyRajiv Gandhi Cancer Institute &

    Research CentreDelhi;

    Department of Histopathology and CytopathologyRajiv Gandhi Cancer Institute &

    Research CentreDelhi;

    Department of Histopathology and CytopathologyRajiv Gandhi Cancer Institute &

    Research CentreDelhi;

    Department of Histopathology and CytopathologyRajiv Gandhi Cancer Institute &

    Research CentreDelhi;

    Department of Histopathology and CytopathologyRajiv Gandhi Cancer Institute &

    Research CentreDelhi;

    Department of Histopathology and CytopathologyRajiv Gandhi Cancer Institute &

    Research CentreDelhi;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 乳房;
  • 关键词

    ASCO / CAP; breast; FISH; HER 2; immunohistochemistry;

    机译：asco / cap;乳房;鱼;她2;免疫组化;

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