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首页> 外文期刊>The clinical respiratory journal. >Use of TBAg/PHA ratio in distinguishing tuberculoma from cancer in solitary pulmonary nodule or mass
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Use of TBAg/PHA ratio in distinguishing tuberculoma from cancer in solitary pulmonary nodule or mass

机译：在孤立性肺结结或质量中，使用TBAG / PHA比例在区分结核瘤中的癌症

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Abstract Introduction Differentiation of tuberculoma from cancer in solitary pulmonary nodule or mass still remains a major challenge in diagnostic laboratories. Objectives The objective of this study is to determine the performance of T‐SPOT.TB assay in discriminating these 2 diseases. Methods We prospectively enrolled 331 patients with a solitary pulmonary nodule or mass on computed tomography scans. Conventional tests and T‐SPOT.TB assay were simultaneously performed in all participants. Results Our results showed that the performance of directly using T‐SPOT.TB results in distinguishing tuberculoma from cancer in solitary pulmonary nodule or mass was not satisfactory because of moderate sensitivity and specificity. However, a further calculation of the ratio of TB‐specific antigen (TBAg) to phytohemagglutinin (PHA) (TBAg/PHA ratio) of T‐SPOT.TB assay may lead to improvement in distinguishing these 2 diseases. If using the threshold value of 0.236, the sensitivity and specificity of the TBAg/PHA ratio in distinguishing tuberculoma from cancer in solitary pulmonary nodule or mass were, respectively, 80.6% and 93.3%. The area under the curve (AUC) of the receiver operating characteristic curve was 0.921 (95% confidence interval, 0.875‐0.967). Furthermore, the TBAg/PHA ratio may also be used to distinguish tuberculoma from other benign diseases (AUC: 0.909, sensitivity: 85.07%, specificity: 90%). Conclusions Calculation of the TBAg/PHA ratio might provide a useful non‐invasive tool for distinguishing tuberculoma from cancer in patients with a solitary pulmonary nodule or mass in TB‐endemic countries.
机译：摘要孤立肺结结构或肿块中癌症从癌症中引入分化仍然是诊断实验室的主要挑战。目的本研究的目的是确定T-Spot.tb测定在鉴别这两种疾病时的性能。方法我们展示了331例患有孤独的肺结核或质量的肺结核扫描。在所有参与者中同时进行常规测试和T-Spot.tb测定。结果我们的研究结果表明，直接使用T-Spot.TB的性能导致孤立肺结结核中的癌症与癌症的结核瘤不令人满意，因为中度敏感性和特异性都不令人满意。然而，进一步计算T-Spot.TB测定的Tb特异性抗原（TBAG）与植物血小葡聚糖素（PHA）（TBAG / PHA比）的比率可能导致在区分这两种疾病方面的改善。如果使用0.236的阈值，则分别在孤立肺结结构或质量中区分结核瘤的TBAG / PHA比的敏感性和特异性分别为80.6％和93.3％。接收器操作特性曲线的曲线（AUC）下的区域为0.921（95％置信区间，0.875-0.967）。此外，TBAG / PHA比率也可用于区分结核瘤（AUC：0.909，敏感性：85.07％，特异性：90％）。结论TBAG / PHA比率的计算可以提供一种有用的非侵入性工具，用于区分结核瘤免疫癌症患者患者患有TB-流行国家的患者。

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  • 来源
    《The clinical respiratory journal.》 |2018年第3期|共9页
  • 作者

    Wang Feng; Hou Hongyan; Zhou Hongmin; Wu Shiji; Mao Lie; Huang Min; Yin Botao; Huang Jing; Sun Ziyong;

  • 作者单位

    Department of Clinical LaboratoryTongji Hospital Tongji Medical College Huazhong University of;

    Department of Clinical LaboratoryTongji Hospital Tongji Medical College Huazhong University of;

    Department of Cardiothoracic SurgeryTongji Hospital Tongji Medical College Huazhong University of;

    Department of Clinical LaboratoryTongji Hospital Tongji Medical College Huazhong University of;

    Department of Clinical LaboratoryTongji Hospital Tongji Medical College Huazhong University of;

    Department of Clinical LaboratoryTongji Hospital Tongji Medical College Huazhong University of;

    Department of Clinical LaboratoryTongji Hospital Tongji Medical College Huazhong University of;

    Department of Clinical LaboratoryTongji Hospital Tongji Medical College Huazhong University of;

    Department of Clinical LaboratoryTongji Hospital Tongji Medical College Huazhong University of;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 呼吸系及胸部疾病;
  • 关键词

    cancer; TBAg/PHA ratio; T‐SPOT; tuberculoma;

    机译：癌症;TBAG / PHA比例;T-斑;结核瘤;

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