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首页> 外文期刊>The British journal of psychiatry : >Longitudinal associations of affective symptoms with mid-life cognitive function: evidence from a British birth cohort
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Longitudinal associations of affective symptoms with mid-life cognitive function: evidence from a British birth cohort

机译：情感症状与中生认知功能的纵向关联：来自英国出生队列的证据

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Background Affective disorders are associated with poorer cognition in older adults; however, whether this association can already be observed in mid-life remains unclear. Aims To investigate the effects of affective symptoms over a period of 30 years on mid-life cognitive function. First, we explored whether timing (sensitive period) or persistence (accumulation) of affective symptoms predicted cognitive function. Second, we tested how different longitudinal trajectories of affective symptoms were associated with cognitive function. Method The study used data from the National Child Development Study. Memory, verbal fluency, information processing speed and accuracy were measured at age 50. Affective symptoms were measured at ages 23, 33, 42 and 50 and used to derive longitudinal trajectories. A structured modelling approach compared a set of nested models in order to test accumulation versus sensitive period hypotheses. Linear regressions and structural equation modelling were used to test for longitudinal associations of affective symptoms with cognitive function. Results Accumulation of affective symptoms was found to be the best fit for the data, with persistent affective symptoms being associated with poorer immediate memory (b = -0.07, s.e. = 0.03, P = 0.01), delayed memory (b = -0.13, s.e. = 0.04, P < 0.001) and information processing accuracy (b = 0.18, s.e. = 0.08, P = 0.03), but not with information processing speed (b = 3.15, s.e. = 1.89, P = 0.10). Longitudinal trajectories of repeated affective symptoms were associated with poorer memory, verbal fluency and information processing accuracy. Conclusions Persistent affective symptoms can affect cognitive function in mid-life. Effective management of affective disorders to prevent recurrence may reduce risk of poor cognitive outcomes and promote healthy cognitive ageing. Declaration of interest None.
机译：背景技术情感障碍与老年人的认知较差;但是，在中期中是否可以观察到这种关联仍然不清楚。旨在调查情感症状在中生认知功能的30年间的影响。首先，我们探讨了情感症状预测认知功能的时间（敏感时期）或持久性（积累）。其次，我们测试了情感症状的不同纵向轨迹与认知功能有关。方法研究来自国家儿童发展研究的数据。记忆，口头流畅性，信息处理速度和准确度在50岁时测量。在23,33,42和50岁测量的情感症状，并用于导出纵向轨迹。结构化建模方法比较了一组嵌套模型，以便测试累积与敏感期假设。线性回归和结构方程建模用于测试情感症状与认知功能的纵向关联。结果累积情感症状的累积是最适合数据的，持续情感症状与较差的立即内存相关（B = -0.07，SE = 0.03，P = 0.01），延迟存储器（B = -0.13，SE = 0.04，P <0.001）和信息处理精度（B = 0.18，SE = 0.08，P = 0.03），但不是信息处理速度（B = 3.15，SE = 1.89，P = 0.10）。重复情感症状的纵向轨迹与较差的记忆，口头流畅性和信息处理准确性有关。结论持续的情感症状会影响中生中的认知功能。有效管理情感障碍以防止复发可能降低认知结果不良的风险，促进健康的认知老龄化。申报感兴趣没有。

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