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首页> 外文期刊>The European Journal of Neuroscience >A resting-state fMRI study of obese females between pre- and postprandial states before and after bariatric surgery
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A resting-state fMRI study of obese females between pre- and postprandial states before and after bariatric surgery

机译：肥胖手术前后和后爆发前后的肥胖女性的休息状态FMRI研究

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Past studies utilizing resting-state functional MRI (rsfMRI), have shown that obese humans exhibit altered activity in brain areas related to reward compared to normal-weight controls. However, to what extent bariatric surgery-induced weight loss alters resting-state brain activity in obese humans is less well-studied. Thus, we measured the fractional amplitude of low-frequency fluctuations from eyes-closed, rsfMRI in obese females (a7=11, mean age = 42 years, mean BMI = 41 kg/m2) in both a pre- and postprandial state at two time points: four weeks before, and four weeks after bariatric surgery. Several brain areas showed altered resting-state activity following bariatric surgery, including the putamen, insula, cingulate, thalamus and frontal regions. Activity augmented by surgery was also dependent on prandial state. For example, in the fasted state, activity in the middle frontal and pre- and postcentral gyri was found to be decreased after surgery. In the sated state, activity within the insula was increased before, but not after surgery. Collectively, our results suggest that resting-state neural functions are rapidly affected following bariatric surgery and the associated weight loss and change in diet.
机译：过去的研究利用休息状态功能MRI（RSFMRI），表明，与正常重量控制相比，肥胖人类表现出与奖励相关的脑区的改变活性。然而，在多大程度上在多大程度上在多大程度上在多大程度上在肥胖人类中改变了休息状态的脑活动。因此，我们在肥胖女性（A7 = 11，平均年龄= 42岁的A7 = 11，平均年龄= 42岁）中测量了低频波动的分数幅度（A7 = 11，平均年龄= 42岁），两者在两者中的前后状态时间点：前四周，牛肝外科后四周。在肥胖手术后，几个脑区显示出育龄活动改变，包括腐库，insula，Cingulate，丘脑和前部区域。由手术增强的活动也依赖于折补状态。例如，在禁食状态下，在手术后发现中间和后和后和后和后中央吉尔的活性降低。在举例的状态下，肠内内的活动以前增加，但手术后没有增加。统称，我们的结果表明，在牛肝外科和相关的减肥和饮食变化之后，静态神经功能迅速影响。

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