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首页> 外文期刊>The European Journal of Neuroscience >Temporal refinement of sensory-evoked activity across layers in developing mouse barrel cortex
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Temporal refinement of sensory-evoked activity across layers in developing mouse barrel cortex

机译：跨越小鼠桶皮层跨层的感觉诱发活性的时间细化

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摘要

Rhythmic whisking behavior in rodents fully develops during a critical period about 2 weeks after birth, in parallel with the maturation of other sensory modalities and the onset of exploratory locomotion. How whisker-related sensory processing develops during this period in the primary somatosensory cortex (S1) remains poorly understood. Here, we characterized neuronal activity evoked by single- or dual-whisker stimulation patterns in developing S1, before, during and after the occurrence of active whisking. Employing multi-electrode recordings in all layers of barrel cortex in urethane-anesthetized mice, we find layer-specific changes in multi-unit activity for principal and neighboring barrel columns. While whisker stimulation evoked similar early responses (0-50 ms post-stimulus) across development, the late response (50-150 ms post-stimulus) decreased in all layers with age. Furthermore, peak onset times and the duration of the late response decreased in all layers across age groups. Responses to paired-pulse stimulation showed increases in spiking precision and in paired-pulse ratios in all cortical layers during development. Sequential activation of two neighboring whiskers with varying stimulus intervals evoked distinct response profiles in the activated barrel columns, depending on the direction and temporal separation of the stimuli. In conclusion, our findings indicate that the temporal sharpening of sensory-evoked activity coincides with the onset of active whisking.
机译：啮齿动物中的节奏搅拌行为在出生后约2周后的关键时期完全发展，与其他感官模态的成熟和探索性运动的发作并行。牙科士相关的感官加工在原发性躯体感觉皮质（S1）中的这种时期发生发展仍然很差。在此，我们在主动搅拌的发生之前，期间和之后，在显影S1中的单晶型刺激模式引起神经元活动。在氨基甲酸酯麻醉的小鼠中使用桶皮质层中的多电极记录，我们在主体和邻近桶列中找到了多单元活动的层特异性变化。虽然晶须刺激在发育中诱发了类似的早期反应（0-50毫秒），但随着年龄增长的所有层，所有层次的晚期响应（50-150毫秒）减少。此外，迄今为止跨年龄组的所有层次减少峰值峰值时间和后期反应的持续时间。对配对脉冲刺激的反应显示在开发过程中所有皮质层中的尖峰精度和配对脉冲比增加。两种相邻晶须的顺序激活具有不同刺激间隔的不同刺激间隔诱发激活的筒柱中的不同响应曲线，这取决于刺激的方向和时间分离。总之，我们的研究结果表明，感觉诱发活性的时间锐化与主动搅拌器的发作一致。

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