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首页> 外文期刊>The European Journal of Neuroscience >Basolateral amygdala supports the maintenance of value and effortful choice of a preferred option
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Basolateral amygdala supports the maintenance of value and effortful choice of a preferred option

机译：Basolateral Amygdala支持维护价值和努力选择的首选选择

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The basolateral amygdala (BLA) is known to be involved in appetitive behavior, yet its role in cost-benefit choice of qualitatively different rewards (more/less preferred), beyond magnitude differences (larger/smaller), is poorly understood. We assessed the effects of BLA inactivations on effortful choice behavior. Rats were implanted with cannulae in BLA and trained to stable lever pressing for sucrose pellets on a progressive ratio schedule. Rats were then introduced to a choice: chow was concurrently available while they could work for the preferred sucrose pellets. Rats were infused with either vehicle control (aCSF) or baclofen/muscimol prior to test. BLA inactivations produced a significant decrease in lever presses for sucrose pellets compared to vehicle, and chow consumption was unaffected. Inactivation had no effect on sucrose pellet preference when both options were freely available. Critically, when lab chow was not concurrently available, BLA inactivations had no effect on the number of lever presses for sucrose pellets, indicating that primary motivation in the absence of choice remains intact with BLA offline. After a test under specific satiety for sucrose pellets, BLA inactivation rendered animals less sensitive to devaluation relative to control. The effects of BLA inactivations in our task are not mediated by decreased appetite, an inability to perform the task, a change in food preference, or decrements in primary motivation. Taken together, BLA supports the specific value and effortful choice of a preferred option.
机译：已知基石运动amygdala（BLA）参与满意行为，但其在成本效益选择中的作用是定性不同的奖励（更多/不那么优选），超越幅度差异（更大/更小）。我们评估了BLA失活对精力选择行为的影响。将大鼠植入BLA中的套管，并训练以稳定的杠杆在渐进式比例上对蔗糖颗粒进行压制。然后将大鼠引入一个选择：在它们可以为优选的蔗糖颗粒工作时同时可用。在试验之前，大鼠用载体对照（ACSF）或Baclofen / Muscimol注入。与载体相比，BLA灭活产生蔗糖颗粒的杠杆压力机的显着降低，并且不受欢迎。当两种选择自由可用时，灭活对蔗糖颗粒偏好没有影响。批判性地，当实验室食物不同时使用时，BLA失活对蔗糖颗粒的杠杆压力机的数量没有影响，表明在没有选择的情况下的主要动机仍然与BLA离线保持完整。在对蔗糖颗粒的特定饱令的测试下进行测试后，BLA灭活使得与对照相对于对照的贬值敏感。 BLA失活在我们任务中的影响不是通过减少的胃口来介导的，无法执行任务，食物偏好的变化，或初级动机的减少。携带在一起，BLA支持优选选项的特定价值和精力化。

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