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首页> 外文期刊>The European Journal of Neuroscience >Beta band oscillatory deficits during working memory encoding in adolescents with attention-deficit hyperactive disorder
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Beta band oscillatory deficits during working memory encoding in adolescents with attention-deficit hyperactive disorder

机译：β带振荡缺陷在青少年中的工作存储器期间，具有注意力过度活跃障碍的青少年

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摘要

Attention-deficit hyperactivity disorder (ADHD) is a neurobehavioural disorder, characterized by symptoms of inattention and/or hyperactivity/impulsivity, in addition to various cognitive deficits, including working memory impairments. This pathology arises from a complex constellation of genetic, structural and neurotransmission abnormalities, which give rise to the aberrant electrophysiological patterns evident in patients with ADHD. Among such, findings have consistently provided support in favour of weaker power across the beta frequency range. Evidence has also emerged that beta rhythmic decrements are linked to working memory encoding. The catecholaminergic modulation of both working memory and beta oscillations may suggest that the link between the two might be rooted at the neurotransmission level. Studies have consistently shown that ADHD involves significant catecholaminergic dysregulation, which is also supported by other clinical studies that demonstrate stimulant-induced amelioration of ADHD symptomology. In this study, we explore the possible ways that might relate ADHD, working memory, beta rhythms and catecholaminergic signalling altogether by investigating the integrity of encoding-relevant electroencephalographic beta rhythms in medication-naive and stimulant-medicated adolescent patients. The aberrant parietal and frontal encoding-related beta rhythm revealed in the ADHD patients together with a working memory (WM) deficit as observed herein was reversed by methylphenidate in the latter case but not with regard to the beta rhythm. This finding per se raises the issue of the role played by beta rhythms in the WM deficits associated with ADHD.
机译：注意力缺陷多动障碍（ADHD）是一种神经热爱障碍，其特征在于，除了各种认知缺陷之外，还包括疏忽和/或多动/冲动的症状，包括工作记忆障碍。该病理学源于复杂的遗传，结构和神经递血异常的星座，这引起了ADHD患者的异常电生理学模式。其中，发现在β频率范围内始终提供支持的支持。证据还出现了β节奏下降与工作内存编码有关。工作记忆和β振荡的儿茶酚胺能调制可能表明两者之间的链路可能根植于神经递质水平。研究一致地表明，ADHD涉及显着的儿茶酚胺能量诱导，其其他临床研究也支持兴奋剂诱导的ADHD症状的改善。在这项研究中，我们通过研究药物 - 幼稚和兴奋剂药剂青少年患者的编码相关的脑电图β节奏的完整性，探讨了可能涉及ADHD，工作记忆，β节奏和儿茶酚酰胺能信号的可能方法。在ADHD患者中揭示的异常图介质和前部编码相关的β节奏与本文所观察到的工作记忆（WM）缺陷在后一种情况下甲基透明剂反转，但不适用于β节奏。此发现本身提出了与ADHD相关的WM赤字中Beta节律发挥的作用问题。

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