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首页> 外文期刊>The European Journal of Neuroscience >Lysosomal LAMP1 immunoreactivity exists in both diffuse and neuritic amyloid plaques in the human hippocampus
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Lysosomal LAMP1 immunoreactivity exists in both diffuse and neuritic amyloid plaques in the human hippocampus

机译：人类海马中的弥漫性和神经炎淀粉样蛋白斑块存在溶酶体灯1免疫反应性

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摘要

Lysosomal vesicles around neuritic plaques are thought to drive Alzheimer's disease by providing ideal microenvironments for generation of amyloid-? Although lysosomal vesicles are present at every amyloid plaque in mouse models of Alzheimer's disease, the number of amyloid plaques that contain lysosomal vesicles in the human brain remains unknown. This study aimed to quantify lysosomal vesicles at amyloid plaques in the human hippocampus. Lysosome-associated membrane protein 1 (LAMP1)-positive vesicles accumulated in both diffuse (A?2-positive/AT8-negative) and neuritic (A?2-positive/AT8-positive) plaques in all regions were analysed. In contrast to mouse models of Alzheimer's disease, however, not all amyloid plaques accumulated LAMP1-positive lysosomal vesicles. Even at neuritic plaques, LAMP1 immunoreactivity was more abundant than phospho-tau (AT8). Further, lysosomal vesicles colocalised weakly with phospho-tau such that accumulation of lysosomal vesicles and phospho-tau appeared to be spatially distinct events that occurred within dystrophic neurites. This quantitative study shows that diffuse plaques, as well as neuritic plaques, contain LAMP1 immunoreactivity in the human hippocampus.
机译：神经炎斑块周围的溶酶体囊泡被认为通过提供理想的微环境用于产生淀粉样蛋白的蛋白质 - ？虽然在阿尔茨海默病的小鼠模型中存在溶酶体囊泡，但含有人脑中含有溶酶体囊泡的淀粉样蛋白斑块的数量仍然未知。该研究旨在在人海马中量化淀粉样斑块的溶酶体囊泡。分析了溶酶体相关的膜蛋白1（灯1） - 在弥漫（Aα2阳性/ AT8阴性）和神经炎（Aα2阳性/ AT8阴性）和神经炎（Aα2阳性/ AT8阳性）斑块中积累的阳性囊泡。然而，与阿尔茨海默病的小鼠模型相比，并非所有淀粉样斑块累积灯1阳性溶酶体囊泡。即使在神经炎斑块，灯泡1灯比磷酸钠更丰富（AT8）。此外，用磷酸盐弱分配溶酶体囊泡，使得溶酶体囊泡和磷脂的积累似乎是在营养不良神经牙本质中发生的空间不同的事件。该定量研究表明，漫射斑块以及神经斑块在人类海马中含有灯1免疫反应性。

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