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首页> 外文期刊>The European Journal of Neuroscience >The Arctic/Swedish APP mutation alters the impact of chronic stress on cognition in mice
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The Arctic/Swedish APP mutation alters the impact of chronic stress on cognition in mice

机译：北极/瑞典应用突变改变了慢性胁迫对小鼠认知的影响

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Chronic stress is a major risk factor for developing Alzheimer's disease (AD) and promotes the processing of amyloid precursor protein (APP) to beta-amyloid (A beta). However, the precise relationship of stress and disease-typical cognitive decline is presently not well understood. The aim of this study was to investigate how early life stress may affect cognition in adult mice with and without soluble A beta pathology typical for the early stages of the disease. We focussed on sustained attention and response control, aspects of cognition mediated by the prefrontal cortex that are consistently impaired both in early AD and after chronic stress exposure. Young wild-type mice as well as transgenic arcA beta mice overexpressing the hAPParc/swe transgene were exposed to a chronic unpredictable stress paradigm (age 3-8 weeks). At 15 weeks, these mice were tested on the 5-choice serial reaction time task, a test of sustained attention and executive control. We found that, expectedly, chronic stress increased impulsive choices and impaired sustained attention in wild-type mice. However, the same treatment reduced impulsivity and did not interfere with sustained attention in arcA beta mice. These findings suggest an unexpected interaction between chronic stress and A beta whereby A beta-pathology caused by the hAPParc/swe mutation prevented and/or reversed stress-induced cognitive changes through mechanisms that deserve further investigation. They also indicate that A beta, in modest amounts, may have a beneficial role for cognitive stability, for example by protecting neural networks from the impact of further physiological or behavioural stress.
机译：慢性应激是开发阿尔茨海默病（AD）的主要危险因素，并促进淀粉样蛋白前体蛋白（APP）的加工至β-淀粉样蛋白（β）。然而，目前还没有很好地理解压力和疾病 - 典型认知下降的确切关系。本研究的目的是调查早期寿命如何影响成人小鼠的认知，而没有典型的疾病的早期阶段的典型典型的β病理学。我们侧重于持续关注和反应控制，前额叶皮质介导的认知方面在早期广告和慢性应激暴露后一直受损。年轻的野生型小鼠以及过表达Happarc / SWE转基因的转基因Arcaβ小鼠接触到慢性不可预测的应力范例（3-8周龄）。在15周，这些小鼠在5选择的连续反应时间任务上进行了测试，持续关注和执行控制的测试。我们发现，预期的是，慢性应激增加了脉冲的选择，并且在野生型小鼠中持续受损。然而，相同的治疗减少了冲动，并且不会干扰Arcaβ小鼠的持续注意。这些发现表明，慢性应激和β之间的意外相互作用，由此通过应得进一步调查的机制来阻止和/或反转应力引起的认知变化的β-病理学。它们还表明，以适度的量，β在适度可能具有认知稳定性的有益作用，例如通过保护神经网络免受进一步的生理或行为应激的影响。

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