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首页> 外文期刊>The European Journal of Neuroscience >The ventromedial hypothalamic circuitry and male alloparental behaviour in a socially monogamous rodent species
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The ventromedial hypothalamic circuitry and male alloparental behaviour in a socially monogamous rodent species

机译：腹侧下丘脑电路和社会啮齿动物啮齿动物物种中的男性异前行为

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As prairie voles (Microtus ochrogaster) display spontaneous biparental care, and the ventromedial hypothalamus (VMH) has been implicated in reproductive behaviour, we conducted experiments to test the hypothesis that the VMH neurochemical circuitry is involved in alloparental behaviours in male prairie voles. We compared alloparental behaviours of adult, sexually naive male and female voles-both displayed licking/grooming, huddling and retrieving behaviours towards conspecific pups. We also stained for the immediate-early gene encoded early growth protein Egr-1 in the vole brain. The pup-exposed animals showed levels of Egr-1 staining that was higher in the VMH but lower in the amygdala compared to animals exposed to a pup-sized piece of plastic (control). A retrograde tracer, Fluoro-Gold (FG), was injected into the VMH of male voles that were subsequently tested in the pup exposure or control condition. More FG/Egr-1 cells were detected for glutamatergic (GLU) staining in the ventral bed nucleus of the stria terminalis (BNSTv) and medial amygdala (MeA), whereas less FG/Egr-1 cells were stained for gamma-aminobutyric acid (GABA) in the MeA of the pup-exposed group compared to the control group. Further, the ratio of GLU:GABA expression in FG/Egr-1 projection neurons from both the BNSTv and MeA to the VMH was increased following pup exposure. Finally, pharmacological blockade of either dopamine D1 receptor or oxytocin receptor in the VMH impaired the onset of male alloparental behaviour. Together, these data suggest that the VMH may be involved in the onset of alloparental care and play a role in regulating social approach in male prairie voles.
机译：作为大草原葡萄球菌（MicroTus Ochrogaster）显示自发的千分钟护理，并且腹侧下丘脑（VMH）涉及生殖行为，我们进行了实验以测试VMH神经化学电路参与男性草原损失中的各种通知行为的假设。我们比较了成人，性朴素的男性和女性葡萄球的各种方式 - 展示舔/修饰，蜷缩和检索朝鲜特异性幼崽的行为。我们还染色于野族脑中的早期基因编码的早期生长蛋白EGR-1。与暴露于普通型塑料（对照）的动物相比，幼崽暴露的动物表明VMH中较高，但在杏仁醛中较低，但在杏仁型中较低。将逆行示踪剂，氟 - 金（FG）注入雄性损伤的VMH中，随后在幼崽暴露或对照条件下进行测试。检测更多FG / EGR-1细胞，用于在腹膜（BNSTV）和内侧杏仁盐（MEA）的腹侧床核中染色的谷氨酰胺（Glu）染色，而染色含γ-氨基丁酸染色的FG / EGR-1细胞较少（与对照组相比，GABA）在幼崽的MEA中。此外，在幼崽暴露之后，Glu：GABA表达在FG / EGR-1投影神经元中的比例从BNSTV和MEA两者中的比例增加。最后，VMH中的多巴胺D1受体或催产素受体的药理阻滞损害了男性种类行为的发作。这些数据在一起表明，VMH可能涉及各种通知的发作，并在男性草原群中调节社会方法起作用。

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