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首页> 外文期刊>The European Journal of Neuroscience >Sleep spindles and slow waves in schizophrenia and related disorders: main findings, challenges and future perspectives
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Sleep spindles and slow waves in schizophrenia and related disorders: main findings, challenges and future perspectives

机译：精神分裂症和相关疾病中的睡眠和慢波：主要调查结果，挑战和未来的观点

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Abstract Sleep abnormalities have recently gained renewed attention in patients diagnosed with schizophrenia. Disrupted thalamocortical brain oscillations hold promise as putative biomarkers or endophenotypes of the disorder. Despite an increase in studies related to sleep spindle and slow‐wave activity, findings remain in part contradictory. Although sleep spindle deficits have been confirmed in several groups of patients with chronic, medicated schizophrenia, data on the early stages of the disorder and in unmedicated subjects are still insufficient. Findings on slow‐wave abnormalities are largely inconclusive, possibly due to the different criteria employed to define the phenomenon and to the influence of atypical antipsychotics. In this review, we aim to address the methodological and practical issues that may have limited the consistency of findings across research groups and different patient populations. Given the neurobiological relevance of these oscillations, which reflect the integrity of thalamocortical and cortico‐cortical function, research in this domain should be encouraged. To promote widespread consensus over the scientific and clinical implications of these sleep‐related phenomena, we advocate uniform and sound methodological approaches. These should encompass electroencephalographic recording and analysis techniques but also selection criteria and characterization of clinical populations.
机译：摘要睡眠异常最近在诊断出精神分裂症的患者中获得重新注意。扰乱了ThalamoCortical脑振荡，并将承诺作为诱发的生物标志物或疾病的内心型。尽管与睡眠主轴和慢波活动相关的研究增加，但结果仍然存在矛盾。虽然睡眠主轴缺陷已经在几组慢性，药物精神分裂症的患者中得到证实，但是对疾病的早期阶段和未病受试者的数据仍然不足。慢波异常的调查结果主要是不确定的，可能是由于采用不同的标准来定义现象和非典型抗精神病学的影响。在这篇综述中，我们的目标是解决可能限制了研究组和不同患者人群的调查结果的一致性的方法和实践问题。鉴于这些振荡的神经生物学相关性，这反映了ThalamoCortical和皮质皮质功能的完整性，应鼓励在该领域的研究。为了促进对这些睡眠相关现象的科学和临床影响的广泛共识，我们提倡统一和声音方法。这些应包括脑电图记录和分析技术，还应包括临床群体的选择标准和表征。

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