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首页> 外文期刊>The European Journal of Neuroscience >Sex differences in head-fixed voluntary running behavior in C57BL/6J mice
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Sex differences in head-fixed voluntary running behavior in C57BL/6J mice

机译：C57BL / 6J小鼠头固定自愿行为的性别差异

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Sex differences in running behaviors between female and male mice occur naturally in the wild. Recent experiments using head-fixed mice on a voluntary running wheel have exploited analogous locomotor activity to gain insight into the neural underpinnings of a number of behaviors ranging from spatial navigation to decision-making. It is however largely unknown if sex differences exist between females and males in a head-fixed experimental paradigm. To address this, we characterized locomotor activity in head-fixed female and male C57BL/6J mice on a voluntary running wheel. First, we found that over the initial 7-day period, on average, animals increased both the velocity and the time spent running. Furthermore, we found that female mice habituated to running forward over the initial 2 days of encountering the wheel, while male mice took up to 4 days to habituate to running forward. Taken together, we characterized features of a sexually divergent behavior in head-fixed running that should be considered in experiments employing female and male mice.
机译：在野外，女性和雄性小鼠之间运行行为的性别差异。最近在自愿运行轮上使用头固定小鼠的实验已经利用类似运动的活动，以了解从空间导航到决策的许多行为的神经内衬。然而，如果在头固定的实验范式中女性和男性之间存在性别差异，则这在很大程度上是未知的。为了解决这一点，我们在自愿运行轮上表征了头固定的雌性和雄性C57BL / 6J小鼠的运动活动。首先，我们发现在最初的7天时期，平均而言，动物的速度和花费时间都会增加。此外，我们发现女性小鼠习惯于在遇到车轮的最初2天内向前运行，而雄性小鼠最多需要4天才能养成前进。我们一起服用，在使用女性和雄性小鼠的实验中应考虑的头固定运行中的性行为行为的特征。

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