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首页> 外文期刊>The European Journal of Neuroscience >Exercise during abstinence normalizes ultrastructural synaptic plasticity associated with nicotine-seeking following extended access self-administration
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Exercise during abstinence normalizes ultrastructural synaptic plasticity associated with nicotine-seeking following extended access self-administration

机译：在禁欲期间锻炼正常化与尼古丁寻求延长自助管理后的超微结构突触可塑性

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Nicotine-craving progressively increases, or incubates, over abstinence following extended access self-administration. While not yet examined for nicotine, the incubation of cocaine-seeking is accompanied by changes in synaptic plasticity in the nucleus accumbens. Here, we determined whether such changes also accompany enhanced nicotine-seeking following extended access self-administration and abstinence, and whether exercise, a potential intervention for nicotine addiction, may exert its efficacy by normalizing these changes. Given that in humans, tobacco/nicotine use begins during adolescence, we used an adolescent-onset model. Nicotine-seeking was assessed in male rats following extended access nicotine or saline self-administration (23-hr/day, 10 days) and 10 days of abstinence, conditions known to induce the incubation of nicotine-seeking, using a within-session extinction/cue-induced reinstatement procedure. A subset of rats had 2-hr/day access to a running wheel during abstinence. Ultrastructural alterations of synapses in the nucleus accumbens core and shell were examined using electron microscopy. Nicotine-seeking was elevated following extended access self-administration and abstinence (in sedentary group), and levels of seeking were associated with an increase in the density of asymmetric (excitatory) and symmetric (inhibitory) synapses onto dendrites in the core, as well as longer asymmetric synapses onto spines, a marker of synaptic potentiation, in both the core and shell. Exercise normalized each of these changes; however, in the shell, exercise and nicotine similarly increased the synapse length. Together, these findings indicate an association between nicotine-seeking and synaptic plasticity in the nucleus accumbens, particularly the core, and indicate that the efficacy of exercise to reduce nicotine-seeking may be mediated by reversing these adaptations.
机译：在延长进入自我管理后，尼古丁 - 蠕虫逐渐增加或孵育，或孵育禁欲。虽然尚未检查尼古丁，但寻求的孵育伴有核心宫内突触可塑性的变化。在这里，我们确定这些变化是否还伴随着增强的尼古丁寻求延长进入自我管理和禁欲，以及是否运动，尼古丁成瘾的潜在干预，可以通过使这些变化进行正常化来发挥其功效。鉴于在人类中，烟草/尼古丁使用在青春期期间开始，我们使用了一个青少年开始模型。在延长接入尼古丁或盐水管理（23-Hr /日，10天）和10天的禁欲后，在雄性大鼠中评估尼古丁寻求评估，已知诱导尼古丁寻求孵育的条件，使用内部灭绝/ Cue诱导的恢复程序。大鼠的子集有2小时/天在禁欲期间进入运行轮。使用电子显微镜检查核核心核心和壳体中突出的超微结构改变。在延长的访问自我给药和禁欲之后，寻求尼古丁寻求升高（在久坐症组中），并且寻求水平与核心中的枝形枝形曲线上的不对称（兴奋性）和对称（抑制）突触的增加有关与脊椎和壳体一样更长的不对称突触，在脊柱上，突触潜力的标志物。运动标准化这些变化中的每一个;然而，在壳中，运动和尼古丁同样增加了突触长度。这些发现在一起表明尼古丁斯和突触塑性之间的关联，特别是核心，特别是核心，并且表明运动的功效可以通过逆转这些适应来介导探讨尼古丁寻求探讨。

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