...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Neuroplasticity in cholinergic neurons of the laterodorsal tegmental nucleus contributes to the development of cocaine addiction
【24h】

Neuroplasticity in cholinergic neurons of the laterodorsal tegmental nucleus contributes to the development of cocaine addiction

机译：跨越核心核的胆碱能神经元中的神经塑性有助于Cocaine成瘾的发育

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The laterodorsal tegmental nucleus (LDT) is a brainstem nucleus that sends cholinergic, glutamatergic, and gamma-aminobutyric acid (GABA)-ergic projections to the ventral tegmental area (VTA), a key brain region associated with reward information processing and reinforcement learning, and thus, with addiction induced by drugs of abuse, including cocaine. Recent studies have revealed that the LDT, in addition to the VTA, plays important roles in the development and expression of cocaine-induced addiction and stress-induced enhancement of addictive behaviors. Additionally, neuroplasticity induced in LDT cholinergic neurons by repeated cocaine administration critically contributes to these behaviors. Elucidation of the underlying mechanisms of cocaine-induced neuroplasticity in the LDT that influences reward circuit activity may lead to the development of therapeutic strategies to treat cocaine addiction and stress-induced reinstatement of cocaine use. This review summarizes recent progress in the study of the LDT, specifically neuroplasticity in LDT cholinergic neurons induced by cocaine and its functional roles in the development and modulation of addictive behaviors associated with cocaine.
机译：后透过的核心核（LDT）是将胆碱能，谷氨酸和γ-氨基丁酸（GABA） - 氨基丁酸（GABA） - 氨基丁酸（VTA）发送到腹部区域（VTA），这是与奖励信息加工和加固学习相关的关键脑区域，因此，滥用药物诱导的成瘾，包括可卡因。最近的研究表明，除了VTA之外，LDT还在可卡因诱导的成瘾和应力诱导的上瘾行为的增强的发展和表达中起重要作用。另外，通过重复的可卡因管理在LDT胆碱能神经元中诱导的神经塑性致力有助于这些行为。阐明影响奖励电路活动的LDT中可卡因诱导的神经塑性的潜在机制可能导致治疗可卡因成瘾和应激诱导的可卡因恢复的治疗策略的发展。本综述总结了可卡因诱导的LDT胆碱能神经元的LDT，特别是神经塑性的研究进展及其在与可卡因相关的令人上瘾行为的开发和调节中的功能作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号