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首页> 外文期刊>The European Journal of Neuroscience >Uncontrolled eating: a unifying heritable trait linked with obesity, overeating, personality and the brain
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Uncontrolled eating: a unifying heritable trait linked with obesity, overeating, personality and the brain

机译：不受控制的饮食：与肥胖，暴饮暴食，人格和大脑相关的统一遗传性状

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摘要

Many eating-related psychological constructs have been proposed to explain obesity and overeating. However, these constructs, including food addiction, disinhibition, hedonic hunger, emotional eating, binge eating and the like all have similar definitions, emphasizing loss of control over intake. As questionnaires measuring the constructs correlate strongly (r > 0.5) with each other, we propose that these constructs should be reconsidered to be part of a single broad phenotype: uncontrolled eating. Such an approach enables reviewing and meta-analysing evidence obtained with each individual questionnaire. Here, we describe robust associations between uncontrolled eating, body mass index (BMI), food intake, personality traits and brain systems. Reviewing cross-sectional and longitudinal data, we show that uncontrolled eating is phenotypically and genetically intertwined with BMI and food intake. We also review evidence on how three psychological constructs are linked with uncontrolled eating: lower cognitive control, higher negative affect and a curvilinear association with reward sensitivity. Uncontrolled eating mediates all three constructs' associations with BMI and food intake. Finally, we review and meta-analyse brain systems possibly subserving uncontrolled eating: namely, (i) the dopamine mesolimbic circuit associated with reward sensitivity, (ii) frontal cognitive networks sustaining dietary self-control and (iii) the hypothalamus-pituitary-adrenal axis, amygdala and hippocampus supporting stress reactivity. While there are limits to the explanatory and predictive power of the uncontrolled eating phenotype, we conclude that treating different eating-related constructs as a single concept, uncontrolled eating, enables drawing robust conclusions on the relationship between food intake and BMI, psychological variables and brain structure and function.
机译：已经提出了许多与饮食有关的心理结构来解释肥胖和暴饮暴食。然而，这些构建体，包括食物成瘾，未征收，啤酒般的饥饿，情绪饮食，狂犬病等都有类似的定义，强调对摄入的控制丧失。作为测量构建体的调查问卷相互关联（R> 0.5），我们建议应重新考虑这些构建体是单一宽表型的一部分：不受控制的饮食。这种方法可以审查和荟萃分析每个人问卷的证据。在这里，我们描述了不受控制的饮食，体重指数（BMI），食物摄入，人格特征和脑系统之间的强大关联。审查横截面和纵向数据，我们表明不受控制的饮食是表型和基因上与BMI和食物摄入相交。我们还审查有关三种心理构建的证据与不受控制的饮食有关：降低认知控制，更高的负面影响和曲线与奖励敏感性的关联。不受控制的饮食介导与BMI和食物摄入的所有三个构造的关联。最后，我们审查和荟萃分析脑系统可能植入不受控制的饮食：即（i）与奖励敏感性相关的多巴胺培条电路，（ii）额外认知网络维持膳食自我控制和（iii）下丘脑 - 垂体 - 肾上腺轴，Amygdala和海马支持应力反应性。虽然存在不受控制的饮食表型的解释性和预测能力的限制，但我们得出结论，将不同的饮食相关构建视为单一概念，不受控制的饮食，使得能够借鉴食物摄入和BMI，心理变量和大脑之间的关系。结构和功能。

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