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首页> 外文期刊>The European Journal of Neuroscience >Gap junction networks can generate both ripple-like and fast ripple-like oscillations
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Gap junction networks can generate both ripple-like and fast ripple-like oscillations

机译：间隙结网络可以产生类似的纹波和快速的纹波状振荡

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摘要

Fast ripples (FRs) are network oscillations, defined variously as having frequencies of > 150 to > 250 Hz, with a controversial mechanism. FRs appear to indicate a propensity of cortical tissue to originate seizures. Here, we demonstrate field oscillations, at up to 400 Hz, in spontaneously epileptic human cortical tissue in vitro, and present a network model that could explain FRs themselves, and their relation to 'ordinary' (slower) ripples. We performed network simulations with model pyramidal neurons, having axons electrically coupled. Ripples (< 250 Hz) were favored when conduction of action potentials, axon to axon, was reliable. Whereas ripple population activity was periodic, firing of individual axons varied in relative phase. A switch from ripples to FRs took place when an ectopic spike occurred in a cell coupled to another cell, itself multiply coupled to others. Propagation could then start in one direction only, a condition suitable for re-entry. The resulting oscillations were > 250 Hz, were sustained or interrupted, and had little jitter in the firing of individual axons. The form of model FR was similar to spontaneously occurring FRs in excised human epileptic tissue. In vitro, FRs were suppressed by a gap junction blocker. Our data suggest that a given network can produce ripples, FRs, or both, via gap junctions, and that FRs are favored by clusters of axonal gap junctions. If axonal gap junctions indeed occur in epileptic tissue, and are mediated by connexin 26 (recently shown to mediate coupling between immature neocortical pyramidal cells), then this prediction is testable. Fast ripples (FR) are network oscillations, defined variously as having frequencies above 150 Hz to above 250 Hz, of controversial mechanism. FR appear to indicate a propensity of cortical tissue to originate seizures.
机译：快速涟漪（FRS）是网络振荡，可变地定义为具有有争议的机制的具有> 150至> 250 Hz的频率。 FRS似乎表明皮质组织的倾向来源于癫痫发作。在这里，我们在体外展示最多400 Hz的现场振荡，并在体外，并呈现一个可以解释FRS本身的网络模型，以及它们与“普通'（较慢）涟漪的关系。我们用模型金字塔神经元进行网络模拟，具有电耦合的轴突。当动作电位的传导时，涟漪（<250Hz）是有利的，轴突到轴轴，是可靠的。虽然纹波群体活动是定期的，但在相对相中射击各个轴突。当耦合到另一个电池的细胞中发生异位尖峰时，发生来自纹波的开关，本身耦合到其他单元。然后，传播只能在一个方向上开始，适合重新进入的条件。得到的振荡> 250Hz，持续或中断，并且在射击各个轴突时抖动很小。模型FR的形式类似于切除的人癫痫组织中的自发性FRS。在体外，通过间隙结阻滞剂抑制FRS。我们的数据表明，给定的网络可以通过间隙结产生涟漪，FRS或两者，并且FRS由轴突间隙连接的簇占据。如果轴突间隙的结确实发生在癫痫组织中，并且由Connexin 26介导（最近显示在未成熟的新奇锥体细胞之间介导的偶联），则该预测是可测试的。快速涟漪（FR）是网络振荡，在争议机制中不同地定义为高于150Hz至高于250Hz的频率。 FR似乎表明皮质组织的倾向来源于癫痫发作。

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    SimonA.; TraubR.D.; VladimirovN.; JenkinsA.; NicholsonC.; WhittakerR.G.; SchofieldI.; ClowryG.J.; CunninghamM.O.; WhittingtonM.A.;

  • 作者单位

    Institute of Neuroscience The Medical School Newcastle University Newcastle upon Tyne United;

    Department of Physical Sciences IBM T. J. Watson Research Center Yorktown Heights NY 10598;

    Department of Physical Sciences IBM T. J. Watson Research Center Yorktown Heights NY 10598;

    Department of Neurosurgery Royal Victoria Infirmary Newcastle upon Tyne United Kingdom;

    Department of Neurosurgery Royal Victoria Infirmary Newcastle upon Tyne United Kingdom;

    Department of Clinical Neurophysiology Royal Victoria Infirmary Newcastle upon Tyne United;

    Department of Clinical Neurophysiology Royal Victoria Infirmary Newcastle upon Tyne United;

    Institute of Neuroscience The Medical School Newcastle University Newcastle upon Tyne United;

    Institute of Neuroscience The Medical School Newcastle University Newcastle upon Tyne United;

    Hull York Medical School The University of York Heslington United Kingdom;

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  • 正文语种 eng
  • 中图分类 神经病学与精神病学;
  • 关键词

    Epilepsy; Neocortex; Random graph; Seizure onset zone;

    机译：癫痫;Neocortex;随机图;癫痫发作区域;

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